Now showing items 1-13 of 13

    • Ramos-Lewis, William David; 0000-0002-4627-4571 (2020-01-17)
      Department: Cell & Developmental Biology
      Basement membranes are sheet-like extracellular matrixes that can be found on the basal surface of epithelial and endothelial cells, surrounding muscles and other organs, and in association with neurons. In addition to ...
    • Frye, Keyada Briana; 0000-0001-8321-1863 (2020-07-22)
      Department: Cell & Developmental Biology
      Here, we characterize spatial distribution of the Golgi complex in human cells. In contrast to the prevailing view that the Golgi compactly surrounds the centrosome throughout interphase, we observe characteristic differences ...
    • Fomicheva, Maria; 0000-0002-0281-0467 (2021-01-06)
      Department: Cell & Developmental Biology
      Epithelial cells possess intrinsic mechanisms to maintain an appropriate cell density for normal tissue morphogenesis and homeostasis. Defects in such mechanisms likely contribute to hyperplasia and cancer initiation. To ...
    • Guillen, Rodrigo; 0000-0002-9807-6155 (2020-06-16)
      Department: Cell & Developmental Biology
      Human casein kinase 1 delta (CK1δ) and epsilon (CK1ε) are members of a conserved family of ubiquitously expressed serine/threonine kinases that regulate multiple cellular processes including endocytosis, circadian rhythm, ...
    • Snider, Chloe Elizabeth; 0000-0002-7206-675X (2021-02-04)
      Department: Cell & Developmental Biology
      Cytokinesis is the final step in cell division in which two daughter cells physically separate. In order to complete this process, many eukaryotes, including Schizosaccharomyces pombe, assemble an actin- and myosin-based ...
    • Snow, John Patrick; 0000-0002-8569-1431 (2020-05-14)
      Department: Cell & Developmental Biology
      Alternating hemiplegia of childhood (AHC) is a rare and devastating neurodevelopmental disorder caused by de novo heterozygous missense mutations in ATP1A3, a crucial gene encoding the 3 subunit of the Na,K-ATPase (NKA) ...
    • Meyer, Anne R.; 0000-0002-5668-6756 (2020-08-31)
      Department: Cell & Developmental Biology
      The response to injury in the stomach is a balancing act between repair mechanisms and the processes that drive carcinogenesis. While the recruitment of reparative lineages is integral to the protection and restoration of ...
    • Rasmussen, Megan Loraine; 0000-0002-8056-6092 (2021-02-03)
      Department: Cell & Developmental Biology
      The B cell CLL/lymphoma-2 (BCL-2) family of proteins control the mitochondrial pathway of cell death, also known as intrinsic apoptosis. The ability of the cell to sense stress and translate it into a death signal has been ...
    • Popay, Tessa Mary; 0000-0002-4694-8804 (2020-12-06)
      Department: Cell & Developmental Biology
      The oncoprotein transcription factor MYC is a major driver of malignancy and a highly-validated target for development of anti-cancer therapies. It has, however, proven challenging to inhibit MYC directly. Novel strategies ...
    • Taneja, Nilay; 0000-0002-9046-0953 (2020-09-23)
      Department: Cell & Developmental Biology
      The molecular motor myosin-II (MII) generates mechanical tension on the actin cytoskeleton to drive cell shape changes during cell division, cell migration and tissue morphogenesis. How these actomyosin networks generate ...
    • Yang, Xiaodun; 0000-0001-9253-9449 (2020-07-19)
      Department: Cell & Developmental Biology
      Sin3a and Sin3b are paralogous transcriptional coregulators that direct cellular differentiation, survival, and function. Mouse Sin3a and Sin3b are co-produced in most pancreatic cells during embryogenesis but become much ...
    • Guarnaccia, Alissa duPuy; 0000-0003-4195-2158 (2021-02-10)
      Department: Cell & Developmental Biology
      WDR5 is a conserved WD40-repeat protein that rose to prominence through its role in epigenetic complexes, including the KMT2 (MLL/SET) enzymes that deposit histone H3 lysine 4 methylation and the non-specific lethal complex ...
    • Foshage, Audra; 0000-0002-8161-0884 (2020-01-16)
      Department: Cell & Developmental Biology
      WDR5 is a highly-conserved nuclear protein that performs multiple scaffolding functions in the context of chromatin. Efforts to better understand WDR5 have been complicated by its many functions in the nucleus, and thwarted ...