Browsing Electronic Theses and Dissertations by Author "Bachmann, Brian O"
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Biosynthetic Derivatization of Antimicrobial Orthosomycins to Engage a Unique Ribosomal Binding Site Yñigez-Gutierrez, Audrey Elizabeth; 0000-0002-8215-8586 (2021-02-19)Department: ChemistryAntimicrobial resistance is a critical threat to human health that results in an estimated 100,000 deaths in the United States each year, according to the World Health Organization. This growing crisis demands the development ...
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Balsamo, Joseph Anthony; 0000-0003-3646-9364 (2022-06-14)Department: PharmacologyNatural products isolated from bacteria impact many current anti-cancer medical interventions. Some natural products induce injury processes in malignant tumors that recruit and activate host immune cells to produce an ...
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Reisman, Benjamin Joshua; 0000-0001-7847-2612 (2021-05-17)Department: Chemical & Physical BiologyCancer is a disease in need of selectively cytotoxic agents – ‘magic bullets’ which target cancerous cells while sparing healthy cells. Microbial secondary metabolites represent a rich source of clinically useful compounds ...
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Synthetic Studies on Hemiketal E2 and 5-Hydroxy Prostaglandin E2 Novel Arachidonic Acid Metabolites Allweil, Alexander Abraham; 0000-0002-9725-516X (2021-10-06)Department: ChemistryThe metabolites of arachidonic acid have long been studied for their intimate role in the human body inflammatory pathway. Inflammation is the body’s natural defense against foreign pathogens and maintains the body’s ability ...