Browsing Electronic Theses and Dissertations by Department "Chemistry"
Now showing items 81-100 of 363
-
(2019-07-18)Department: ChemistryThe manipulation and tailoring of crosslinked materials to engineer new materials with enhanced properties has been a growing field of interest in the past decade. Recent advances in light-mediated polymerizations such ...
-
(2015-02-23)Department: ChemistryOne family of platforms to probe molecular interactions utilizes interferometry. Interferometry has a major advantage over other techniques in that it does not require the use of labels, which could affect interactions ...
-
(2018-03-27)Department: ChemistryThe aim of this research was to develop strategies to advance ion mobility-mass spectrometry (IM-MS) studies via both the development of a novel, spatially multiplexed instrument and the conformational analyses of biomolecules, ...
-
(2012-12-14)Department: ChemistryI describe a methodology for preparing and using a standard target for calibrating, laser alignment and focusing of MALDI imaging mass spectrometry instruments. The target is constructed by simple detachment patterning ...
-
(2014-07-17)Department: ChemistryCuInS2 is a ternary semiconductor material with potential alternative energy applications in photovoltaic devices and in systems designed for photocatalytic water reduction. To date, the majority of research into CuInS2 ...
-
(2020-06-02)Department: ChemistryHere in, we describe the optimization of high-affinity, choline up-take transporter (CHT) antagonist, ML352, to improved in vivo tool compound, VU6001221. VU6001221, a potent and selective CHT inhibitor with significantly ...
-
(2021-08-13)Department: ChemistryBiohybrid solar cells utilizing the plant protein complex Photosystem I (PSI) as the key photoactive ingredient are studied for their ability to reduce the cost and environmental impacts of solar energy harvesting technologies. ...
-
(2017-07-20)Department: ChemistryPolymeric nanoparticles have historically been shown to be valuable tools for the solubilization and delivery of small molecule hydrophobic drugs. However, most systems do not address obstacles associated with off-target ...
-
(2024-03-12)Department: ChemistryPreterm birth (PTB) constitutes 10% of births and is the global leading cause of death in children under the age of 5. Unfortunately, a complete understanding of the mechanisms precluding PTB is lacking, making prediction ...
-
(2021-07-15)Department: ChemistryMalaria is a lethal infectious disease which is estimated to cause 229,000,000 cases worldwide, with 409,000 deaths. In this work, two methods are explored to enhance the efficacy and utility of malaria control and elimination ...
-
(2016-03-11)Department: ChemistrySystems biology greatly enhances the study of complex biological processes by expanding on reductionist approaches that have traditionally focused on individual biological components (i.e. glycomics). Systems biology ...
-
(2017-02-03)Department: ChemistryG protein-gated inwardly rectifying potassium (GIRK) ion channels are part of a larger family of inwardly rectifying potassium channels (Kirs) that regulate diverse biological processes. Kirs regulate solute balance in the ...
-
(2008-12-22)Department: ChemistryMultianalyte microphysiometry is a real-time method for evaluating cellular metabolism using the multianalyte microphysiometer (MAMP), an instrument capable of measuring extracellular changes in the flux rates of oxygen, ...
-
(2011-04-15)Department: ChemistryNovel ion mobility-mass spectrometry shift reagents have been developed in order to facilitate rapid identification of specific functionalities within a complex mixture of peptides. Lanthanide chelating labels provide great ...
-
(2017-08-25)Department: ChemistryRegenerative medicine and drug delivery strategies require the use of advanced materials that can mimic the complex biological environment of native tissues. We present a series of advanced poly(glycidol) networks that are ...
-
(2012-04-10)Department: ChemistryMetabotropic glutamate (mGlu) receptors are examples of family C G-protein-coupled receptors that possess vast roles in the pathophysiology of central nervous system (CNS) disorders. In order to fully understand the mGlu ...
-
(2018-04-16)Department: ChemistryThe three diseases most commonly linked to poverty—malaria, tuberculosis (TB), and HIV/AIDS—are the cause of 8.7 million deaths globally each year. Early and accurate diagnosis of these infectious disease is critically ...
-
(2013-04-16)Department: ChemistryDisorders of the central nervous system (CNS) continue to be among mankind’s most devastating illnesses. Along with causing enormous suffering for those affected, mental disorders place an extreme socioeconomic burden on ...
-
(2015-07-22)Department: ChemistryDelivery of diagnostic tools to low-resource settings under the burden of the malaria epidemic faces numerous challenges. These underdeveloped areas are often characterized by poverty, absent or intermittent electricity, ...
-
(2017-04-11)Department: ChemistryIn low-resource areas of the world, accurate diagnosis of disease is especially challenging, as resources are limited and environmental conditions uncontrolled. Consequently, reliable low-resource diagnostics must be simple, ...