Browsing Electronic Theses and Dissertations by Department "Cancer Biology"
Now showing items 81-100 of 161
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(2008-04-22)Department: Cancer BiologyMatrix metalloproteinases (MMPs) are classically associated with late stage metastases, though previous work by our lab and others have expanded the role of MMPs to all stages of tumor development. Using a genetic model ...
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(2010-04-10)Department: Cancer BiologyThe Eph family of receptor tyrosine kinases has important roles in multiple aspects of cancer development and progression. Substantial advances have been made in understanding the Eph receptor signalling in the pathways ...
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(2011-01-31)Department: Cancer BiologyProstate cancer is the second most common form of cancer in men. Despite the alarming figures and decades of research, a cure still eludes prostate cancer patients. The morbidity associated with advanced prostate cancer ...
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(2016-11-29)Department: Cancer BiologyIn spite of recent advances in therapy, cancer remains a leading cause of death worldwide. Therapy response is often unpredictable and relapse frequently occurs. In many cases, this therapy resistance is attributed to ...
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(2008-03-19)Department: Cancer BiologyThe development of cancer in humans is characterized by the accumulation of genetic alterations that either enhance or diminish activity in signaling pathways mediating cellular growth and proliferation. Over time these ...
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(2011-04-02)Department: Cancer Biologyp120 catenin (p120) binds and stabilizes classical cadherins, making it a critical regulator of cell-cell adhesion. Here, we report an efficient technique (designated ReCLIP for Reversible Cross-Link Immuno-Precipitation) ...
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(2010-12-10)Department: Cancer BiologyOverexpression of activated oncogenes such as Ras(V12) in primary cells induces senescence rather than transformation, thus suppressing tumorigenesis. C/EBPbeta is required for Ras(V12)-induced senescence in mouse embryonic ...
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(2008-03-06)Department: Cancer BiologyChemokines are a family of small chemotactic cytokines that bind seven transmembrane G protein-coupled receptors. Roles for CXC chemokines and the receptors CXCR2 and CXCR4 in inflammation-mediated tumorigenesis, angiogenesis, ...
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(2011-09-26)Department: Cancer BiologySynovial sarcoma (SS) is a rare but aggressive malignancy that is typically diagnosed in adolescents and young adults. These tumors are characterized by the presence of a specific chromosomal translocation t(X;18)(p11.2;q11.2) ...
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(2010-09-22)Department: Cancer BiologyProgression to castrate resistant prostate cancer (CRPC) is associated with high morbidity. Disease recurrence and progression is influenced by the tumor microenvironment. Resident and recruited stroma contribute to cancer ...
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(2007-04-14)Department: Cancer BiologyAlthough many studies have investigated the pro- and anti-apoptotic functions of the Bcl-2 family of proteins, it has been found that the anti-apoptotic Bcl-2 and Bcl-xL molecules also have a role in the cell cycle. It has ...
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(2018-04-12)Department: Cancer BiologyCell motility is a process tightly linked to tumor metastasis. The p21-activated kinases (PAKs) are modulators of cell motility commonly overexpressed and hyperactive in various malignancies. We investigated whether ...
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(2012-07-26)Department: Cancer BiologyTransforming growth factor-beta (TGF-β) has a dual role during tumor progression initially as a suppressor and then as a promoter. Much is known about the contribution of TGF-β signaling to tumorigenesis, yet, the role ...
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(2010-04-01)Department: Cancer BiologyTAL1/SCL encodes a basic helix-loop-helix transcription factor and was first identified through its involvement in a chromosomal translocation in T-cell acute lymphoblastic leukemia. The mouse Tal1 cDNA was cloned from a ...
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(2015-03-18)Department: Cancer BiologyCANCER BIOLOGY Roles of Fibroblast MMP2 in Breast to Lung Metastasis Andreia L. Bates Dissertation under the direction of Barbara Fingleton, PhD Breast cancer five-year survival rates decrease from 99% for patients ...
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(2023-07-20)Department: Cancer BiologyAlthough selenium deficiency correlates with colorectal cancer (CRC) risk, the roles of the selenium-rich antioxidant selenoprotein P (SELENOP) in CRC remain unclear. In this study, we defined SELENOP’s contributions to ...
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(2023-07-20)Department: Cancer BiologyAlthough selenium deficiency correlates with colorectal cancer (CRC) risk, the roles of the selenium-rich antioxidant selenoprotein P (SELENOP) in CRC remain unclear. In this study, we defined SELENOP’s contributions to ...
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(2023-07-20)Department: Cancer BiologyAlthough selenium deficiency correlates with colorectal cancer (CRC) risk, the roles of the selenium-rich antioxidant selenoprotein P (SELENOP) in CRC remain unclear. In this study, we defined SELENOP’s contributions to ...
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(2023-07-20)Department: Cancer BiologyAlthough selenium deficiency correlates with colorectal cancer (CRC) risk, the roles of the selenium-rich antioxidant selenoprotein P (SELENOP) in CRC remain unclear. In this study, we defined SELENOP’s contributions to ...
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(2023-07-20)Department: Cancer BiologyAlthough selenium deficiency correlates with colorectal cancer (CRC) risk, the roles of the selenium-rich antioxidant selenoprotein P (SELENOP) in CRC remain unclear. In this study, we defined SELENOP’s contributions to ...