Browsing Electronic Theses and Dissertations by Department "Pharmacology"
Now showing items 61-80 of 143
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(2006-03-30)Department: PharmacologyIn mammalian cells, phospholipase D activity is tightly regulated by diverse cellular signals including hormones, neurotransmitters, and growth factors. Multiple signaling pathways converge upon phospholipase D to modulate ...
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(2019-01-17)Department: PharmacologyG-protein coupled receptors (GPCRs) represent the largest family of membrane proteins and the most heavily targeted classes of proteins for therapeutic intervention. Relatively little is known about the structure of these ...
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(2010-04-15)Department: PharmacologyMuscarinic acetylcholine receptors (mAChRs), specifically M1 and M4 subtypes, provide viable targets for the treatment of multiple central nervous system disorders. However, highly selective activators of either M1 or M4 ...
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(2023-07-17)Department: Pharmacologytbd
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(2023-07-17)Department: Pharmacologytbd
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(2008-05-02)Department: PharmacologyHeterotrimeric G proteins act as molecular switches in signaling pathways by coupling the activation of heptahelical receptors at the cell surface to intracellular responses. These receptors bind to and activate G proteins ...
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(2018-05-21)Department: PharmacologyMutations in lamin A/C (LMNA) are the second most common contributor to genetic cases of dilated cardiomyopathy (DCM). Despite the autosomal-dominant inheritance of LMNA DCM, gene-targeted mouse models of LMNA DCM show ...
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(2011-11-11)Department: PharmacologyIncreasing evidence supports an integral role for the lipid second messenger phosphatidic acid (PtdOH) in cell signaling. In addition to altering curvature of biological membranes, PtdOH lies at the intersection between ...
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(2020-11-14)Department: PharmacologyThe metabotropic glutamate receptor 7 (mGlu7) is a G protein-coupled receptor that plays important roles in synaptic transmission and plasticity in the brain. mGlu7 is expressed presynaptically on excitatory and inhibitory ...
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(2018-02-13)Department: PharmacologyL-DOPA Induced Dyskinesia (LID) is the motor complication involving an overproduction of movement that arises from L-DOPA treatment of Parkinson's disease (PD). Despite the high incidence of the development of LID, the ...
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(2013-04-15)Department: PharmacologyMetabotropic glutamate receptors (mGluRs) are G protein-coupled receptors that play important roles in the modulation of neurotransmission in the central nervous system (CNS). The eight subtypes of mGluRs are differentially ...
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(2021-11-02)Department: PharmacologyGolgi-resident bisphosphate nucleotidase 2 (BPNT2) is a member of a family of magnesium-dependent phosphatases that are directly inhibited by lithium, the first-line medication for bipolar disorder. BPNT2 is localized to ...
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(2003-02-20)Department: PharmacologyThe serotonin transporter (SERT) mediates clearance of the neuromodulator serotonin (5-HT) following its release. The clinical efficacy of antidepressant drugs that block SERT activity indicates that serotonin transporter ...
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(2017-12-05)Department: PharmacologyModulation of neurotransmitter exocytosis by activated Gi/o coupled G-protein coupled receptors (GPCRs) is a universal regulatory mechanism used both to avoid overstimulation and to influence circuitry. One of the known ...
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(2013-12-03)Department: PharmacologyThe platelet thrombin receptors Protease-activated receptor 1 (PAR1) and Protease activated receptor 4 (PAR4) stand at the intersection of coagulation and platelet activation. Thrombin receptors are thus excellent ...
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(2018-01-22)Department: PharmacologyNeurofibromatosis type 1 results from mutations in NF1, a gene that encodes Neurofibromin. This common genetic condition is associated with tibial pseudarthrosis (PA), whose etiology is unknown but thought to involve ...
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(2006-04-04)Department: PharmacologyADAR2-mediated adenosine-to-inosine (A-to-I) RNA editing can affect the coding potential, splicing pattern, stability, and localization of the targeted RNA transcripts. ADAR2 contains two double-stranded RNA binding motifs ...
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(2014-06-26)Department: PharmacologyThe goal of this project is to better understand the relationship between cardiac sodium channel dysfunction and cardiomyopathy. Mutations in the gene SCN5A, encoding the cardiac sodium channel, typically cause ventricular ...
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(2014-06-11)Department: PharmacologyPHARMACOLOGY Nanonetworks as Innovative Platforms for Therapeutic Solubilization and Delivery David Michael Stevens Dissertation under the direction of Professor Eva M. Harth Solubility remains the biggest obstacle in ...
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(2022-06-14)Department: PharmacologyNatural products isolated from bacteria impact many current anti-cancer medical interventions. Some natural products induce injury processes in malignant tumors that recruit and activate host immune cells to produce an ...