Browsing Electronic Theses and Dissertations by Department "Chemical and Physical Biology"
Now showing items 61-67 of 67
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(2013-12-12)Department: Chemical and Physical BiologyMarineosin A was isolated from a marine sediment-derived actinomycete in 2008. The intriguing biological activity and novel chemical structure warranted completion of the total synthesis of this compound. The model systems ...
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(2013-04-15)Department: Chemical and Physical BiologyThe topological structure of DNA is regulated by ubiquitous enzymes called topoisomerases. Type II topoisomerases resolve supercoils and remove knots and tangles from the genetic material by generating transient breaks in ...
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(2013-07-26)Department: Chemical and Physical BiologyMedical image segmentation has become a vital component of radiation therapy treatment planning over the past two decades. Segmentations are used both to target dose to tumors and assess dose to normal tissues, and they ...
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(2011-05-18)Department: Chemical and Physical BiologyANDREW MORIN Dissertation under the direction of Professor Jens Meiler. Interaction between protein and ligand is a fundamental mechanism in biology. The goal of my dissertation research was to develop a general and ...
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(2013-07-29)Department: Chemical and Physical BiologyThe first total synthesis of (+)-7-bromotrypargine, a β-carboline alkaloid from Ancornia sp. was completed in 9 steps, 8 steps longest linear sequence, and 40% overall yield. Biological characterization found that ...
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(2016-11-08)Department: Chemical and Physical BiologyThe first total synthesis of Gombamide A, a cyclic thiopeptide from the sponge Clathria gombawuiensis, is reported. The convergent synthesis features a disulfide bond forming cascade to close the 17-membered macrocycle and ...
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(2018-02-19)Department: Chemical and Physical BiologyTargeted therapy is an effective standard of care in BRAF-mutated malignant melanoma. However, tumor remission varies unpredictably among patients and relapse is almost inevitable. Surprisingly, most of our current knowledge ...