Browsing Electronic Theses and Dissertations by Department "Pharmacology"
Now showing items 41-60 of 143
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(2012-05-25)Department: PharmacologyMutations in inhibitory GABAA receptor γ2 subunit gene, GABRG2, have been associated with genetic epilepsy syndromes including childhood absence epilepsy (CAE), pure febrile seizures (FS), generalized epilepsy with febrile ...
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(2021-03-22)Department: PharmacologyRegulated exocytosis is the process that directs the release of neurotransmitters and peptide hormones from neurons and endocrine cells. CAPS1, calcium-dependent activator protein for secretion 1, is a SNARE accessory ...
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(2010-04-10)Department: PharmacologyGABA functions as the primary inhibitory neurotransmitter in the mammalian brain. In hippocampus, GABA serves multiple roles during development and throughout adulthood, which include: 1) orchestrate synapse maturation ...
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(2011-07-28)Department: PharmacologyHuntington’s disease is a fatal autosomal dominant neurodegenerative disease caused by an expansion of CAG repeats in the DNA of the Huntingtin gene. The length of the repeat is inversely related to the age of disease ...
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(2019-02-13)Department: PharmacologyDopamine (DA) signaling plays an important role in the central nervous system by regulating a variety of functions including attention, motivation, reward, movement and courtship. Alterations in DA signaling have been ...
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(2016-11-03)Department: PharmacologyThe application of genome science to inherited heart disease requires accurate genetic evaluation and understanding of physiologic resulting from genetic variation. Using a Long QT syndrome phenotype that is very suggestive ...
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(2019-11-18)Department: PharmacologyCardiac kinases play a critical role in the development of heart failure, and represent potential tractable therapeutic targets. However, only a very small fraction of the cardiac kinome has been investigated. To identify ...
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(2014-07-17)Department: PharmacologyPHARMACOLOGY Hypo-osmotic Effects in Cardiovascular Controls: Hepatic and Renal Mechanisms Underlying the Osmopressor Response. Patients with baroreflex impairment experience a robust increase in blood ...
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(2016-03-01)Department: PharmacologyAcetylcholine controls or modulates virtually every physiological process from the regulation of skeletal and smooth muscle contraction, to learning and memory (Sellers & Chess-Williams, 2012). Consequently, alterations ...
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(2019-03-15)Department: PharmacologyAdipose tissue (AT) is a dynamic endocrine organ that contributes to metabolic health. Proper function of resident immune cells is vital to AT function, and thus the pro-inflammatory AT environment during obesity contributes ...
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(2015-11-18)Department: PharmacologyHuman induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) have the potential to be an important tool for cardiovascular disease modeling, pre-clinical cardiotoxicity evaluation, and drug discovery. However, ...
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(2021-06-14)Department: PharmacologyKCC2 is a K+-Cl- cotransporter with neuronal expression throughout the central nervous system. Deficits in KCC2 activity have been implicated in a variety of neurological disorders, including epilepsy, chronic pain, autism ...
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(2014-02-11)Department: PharmacologyThe production of bioactive lipids by phospholipases has long been appreciated as an important mode of cellular communication. Phospholipase D (PLD) enzymes hydrolyze phosphatidylcholine to generate a choline headgroup and ...
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(2023-06-05)Department: PharmacologyBrown adipose tissue (BAT) has in recent times been rediscovered in adult humans, and together with work from preclinical models, shown to have the potential of providing a variety of positive metabolic benefits. These ...
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(2023-09-26)Department: PharmacologyThe plasticity of the adult mammalian brain is determined by the number and proliferation capacity of neural stem cells (NSCs). The pool of NSCs responsible for populating the adult brain is established during prenatal ...
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(2011-03-14)Department: PharmacologyKCNE4 is a potassium channel modulating protein that can dramatically inhibit distinct potassium currents, but we lack a clear understanding its mechanism for doing so and its physiologic significance. In this project we ...
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(2014-07-16)Department: PharmacologySynaptic transmission is characterized by exocytotic events which mediate the release of chemical transmitters to facilitate neuronal communication. Inhibitory presynaptic GPCRs act as feedback regulators limiting transmitter ...
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(2017-05-26)Department: PharmacologyObsessive-compulsive disorder (OCD) is a chronic, disabling condition with inadequate treatment options that leave most patients with substantial residual symptoms. Structural, neurochemical, and behavioral findings point ...
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(2020-01-17)Department: PharmacologyDeficits in social interaction (SI) are a core symptom of Autism Spectrum Disorders (ASD), however treatments for social deficits are notably lacking. Elucidating brain circuits and neuromodulatory signaling systems that ...
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(2022-01-06)Department: PharmacologyThe dynorphin/kappa opioid receptor (KOR) system within the nucleus accumbens (NAc) contributes to negative affective states following withdrawal from illicit drugs, pain, and stress. In the NAc, parvalbumin fast-spiking ...