Browsing Electronic Theses and Dissertations by Department "Cell and Developmental Biology"
Now showing items 41-60 of 179
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(2017-03-29)Department: Cell and Developmental BiologyType 2 diabetes is characterized by failure of pancreatic β-cells to secrete adequate insulin to meet the needs of the body. This β-cell failure is thought to be caused by increased metabolic load due to mounting insulin ...
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(2014-11-06)Department: Cell and Developmental BiologyThe TGF-â ligand Nodal is a key regulator of body axis formation and patterning in the developing vertebrate embryo. How the Nodal signaling pathway is activated and regulated, and how precise spatiotemporal control of ...
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(2013-07-29)Department: Cell and Developmental BiologyIn many organisms, a cytokinetic ring directs daughter cell separation following mitosis. While conserved molecular participants in this process have been defined, the signaling events controlling cytokinetic ring function ...
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(2014-10-10)Department: Cell and Developmental BiologyCELL AND DEVELOPMENTAL BIOLOGY Dominant and Context-Specific Control of Endodermal Organ Allocation by Ptf1a Spencer Gaffney Willet Dissertation under the direction of Professor Christopher V.E. Wright The timing and ...
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(2012-12-14)Department: Cell and Developmental BiologyMyeloid-derived suppressor cells (MDSCs) play an important role in cancer progression. Elucidating the mechanisms involved in the expansion and function of these cells is important in the fight against cancer. A microarray ...
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(2013-07-23)Department: Cell and Developmental BiologyA dense array of parallel actin-based protrusions called microvilli extend from the apical surface of intestinal epithelial cells (IECs), collectively called the brush border. In addition to serving as the sole site of ...
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(2013-11-27)Department: Cell and Developmental BiologyTuberous Sclerosis Complex (TSC) is a multi-organ hamartomatous disease caused by loss of function mutations in either the TSC1 or TSC2 genes. Despite involvement of multiple organs such as the kidneys, lungs, and skin, ...
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(2016-01-13)Department: Cell and Developmental BiologyProper regulation of gene transcription is an essential process for any cell. Failure to precisely control the procedure of transcription can lead to developmental defects, disease, and even death. Within the last 20 years, ...
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(2014-05-27)Department: Cell and Developmental BiologyA critical step during gene expression is the directional export of nuclear messenger (m)RNA through nuclear pore complexes (NPCs) to the cytoplasm. During export, Gle1 in conjunction with inositol hexakisphosphate (IP6) ...
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(2008-12-30)Department: Cell and Developmental BiologyIdentification of multipotent cardiac progenitors has provided fresh insight into the mechanisms of myocardial lineage specification, yet has done little to clarify the origin of the endocardium. Despite its essential role ...
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(2006-04-20)Department: Cell and Developmental BiologyThe lining of the gastrointestinal tract, a single layer of epithelial cells, forms a dynamic barrier that protects the organism from harmful substances present in the lumen. Maintenance of a healthy gastrointestinal tract ...
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(2013-10-01)Department: Cell and Developmental BiologyCELL AND DEVELOPMENTAL BIOLOGY Examination of Hnf6 and downstream effectors in postnatal endocrine function Kathryn D. Henley Dissertation under the direction of Professor Maureen Gannon The pancreas is an ...
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(2018-03-22)Department: Cell and Developmental BiologyCardiac development is a tightly controlled, step-wise process, as the heart is one of the first functional organs to develop. The major cell type of the heart is the cardiomyocyte and is known to be the work horse of the ...
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(2004-04-08)Department: Cell and Developmental BiologyThe ubiquitin-proteasome pathway (UPP) is the principal mechanism for the selective degradation of short-lived proteins. The proximal signal for UPP-mediated proteolysis is the covalent modification of target proteins with ...
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(2006-12-01)Department: Cell and Developmental BiologyAnimal movement is controlled by the motor circuit, which features an axial nerve cord where motor neurons transmit signals from the brain to specific muscles. The development of this circuit depends on differential gene ...
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(2019-09-13)Department: Cell and Developmental BiologyCytokinesis is the physical separation of two daughter cells. Coordination of cytokinesis with genome duplication and segregation is essential for the viability of all cells. Yeast, amoebas, and animal cells assemble an ...
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(2008-12-30)Department: Cell and Developmental BiologyTransport of nucleic acids and proteins between the nucleus and cytoplasm occurs exclusively through nuclear pore complexes (NPCs), large transport channels embedded in the nuclear envelope. Molecules larger than ~40kDa ...
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(2007-10-04)Department: Cell and Developmental BiologyThe process of implantation absolutely depends on synchronized development of the blastocyst to implantation competency, differentiation of the uterus to the receptive state and a reciprocal dialogue between the blastocyst ...
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(2004-10-15)Department: Cell and Developmental BiologyComparative genome analysis implied that a progressively more elaborate regulation of gene expression rather than invention of new genes is responsible for the organismal complexity, and that a constrained organization of ...
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(2013-10-09)Department: Cell and Developmental BiologyThe role of Four jointed box 1 (FJX1) in colorectal cancer (CRC) is presented in this dissertation. FJX1 was identified as a candidate gene for regulating tumor formation in CRC as it was inhibited in rectal cancers after ...