Browsing Electronic Theses and Dissertations by Department "Cell & Developmental Biology"
Now showing items 41-55 of 55
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(2021-06-24)Department: Cell & Developmental BiologyTo better understand how Insm1, Neurod1 and Pax6 contribute to the formation and function of pancreatic endocrine cells I performed comparative immunohistochemical, transcriptomic, functional enrichment, and RNA splicing ...
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(2020-08-31)Department: Cell & Developmental BiologyThe response to injury in the stomach is a balancing act between repair mechanisms and the processes that drive carcinogenesis. While the recruitment of reparative lineages is integral to the protection and restoration of ...
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Revealing MCL-1 Regulation of Mitochondrial Dynamics in Human Pluripotent Stem Cell-Derived Systems (2021-02-03)Department: Cell & Developmental BiologyThe B cell CLL/lymphoma-2 (BCL-2) family of proteins control the mitochondrial pathway of cell death, also known as intrinsic apoptosis. The ability of the cell to sense stress and translate it into a death signal has been ...
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(2023-03-23)Department: Cell & Developmental BiologyRgp1 was previously identified as a component of a guanine nucleotide exchange factor complex to activate Rab6a-mediated Golgi-centric trafficking events. While the role of Rgp1 in protein trafficking has been examined in ...
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(2020-12-06)Department: Cell & Developmental BiologyThe oncoprotein transcription factor MYC is a major driver of malignancy and a highly-validated target for development of anti-cancer therapies. It has, however, proven challenging to inhibit MYC directly. Novel strategies ...
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(2020-09-23)Department: Cell & Developmental BiologyThe molecular motor myosin-II (MII) generates mechanical tension on the actin cytoskeleton to drive cell shape changes during cell division, cell migration and tissue morphogenesis. How these actomyosin networks generate ...
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(2021-10-14)Department: Cell & Developmental BiologyThe surface of the intestinal tract exhibits morphological adaptations at multiple levels of scale, which collectively serve to increase surface area available for nutrient absorption. Large folds of tissue called villi ...
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(2023-06-08)Department: Cell & Developmental BiologyCytokinesis is the final process in the cell cycle which divides two daughter cells. Many eukaryotic organisms use an actin- myosin-based structure known as the cytokinetic ring (CR) to drive cell abscission. The rod-shaped ...
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(2023-06-08)Department: Cell & Developmental BiologyCytokinesis is the final process in the cell cycle which divides two daughter cells. Many eukaryotic organisms use an actin- myosin-based structure known as the cytokinetic ring (CR) to drive cell abscission. The rod-shaped ...
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(2020-07-19)Department: Cell & Developmental BiologySin3a and Sin3b are paralogous transcriptional coregulators that direct cellular differentiation, survival, and function. Mouse Sin3a and Sin3b are co-produced in most pancreatic cells during embryogenesis but become much ...
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(2021-02-10)Department: Cell & Developmental BiologyWDR5 is a conserved WD40-repeat protein that rose to prominence through its role in epigenetic complexes, including the KMT2 (MLL/SET) enzymes that deposit histone H3 lysine 4 methylation and the non-specific lethal complex ...
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(2022-03-29)Department: Cell & Developmental BiologyThe myoepithelial cell compartment of the murine postnatal mammary gland is generated from basal cap cells in the terminal end bud and maintained by self-renewal. Transdifferentiation to the luminal lineage does not normally ...
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(2024-01-30)Department: Cell & Developmental BiologyThe Wnt-beta-catenin signal transduction pathway is essential for animal development and adult tissue homeostasis. Wnt signaling promotes stabilization of beta-catenin, which translocates to the nucleus and binds to TCF/LEF ...
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(2023-11-15)Department: Cell & Developmental BiologyTransporting epithelia of the kidney and small intestine utilize actin-supported cell surface protrusions, known as microvilli, to expand surface area available for solute transport. Microvilli found on the surface of these ...
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(2020-01-16)Department: Cell & Developmental BiologyWDR5 is a highly-conserved nuclear protein that performs multiple scaffolding functions in the context of chromatin. Efforts to better understand WDR5 have been complicated by its many functions in the nucleus, and thwarted ...