Browsing Electronic Theses and Dissertations by Department "Cancer Biology"
Now showing items 41-60 of 161
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(2009-04-21)Department: Cancer BiologyFUNCTIONAL STUDIES ON INTERLEUKIN 24 IN VITRO AND IN VIVO MIAO HE Thesis under the direction of Professor Peng Liang Among IL-20 family of cytokines, IL-19, IL-20 and IL-24 can each activate IL20R1/IL-20R2 heterodimeric ...
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(2008-03-05)Department: Cancer BiologyThere is a significant genetic component to prostate cancer (PrCa) risk. Multiple epidemiologic and linkage studies suggest X-linked heritability. Located at chromosome Xq27-28, HPCX has been identified as a PrCa susceptibility ...
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(2023-10-23)Department: Cancer BiologySarcomas are a rare family of tumors derived from mesenchymal tissues including bone, fat, cartilage, and muscle. Sarcomas vary significantly across histological and molecular subtypes, making them difficult to treat ...
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(2021-12-20)Department: Cancer BiologyBreast cancer cells frequently home to the bone marrow, where they encounter signals that promote survival and quiescence or stimulate their proliferation. However, our mechanistic understanding of bone dissemination and ...
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(2019-11-14)Department: Cancer BiologyRIG-I is a cytoplasmic RNA helicase expressed in most cells of the body, functioning to sense viral oligonucleotide motifs then activate innate immune responses to combat viral infection. RIG-I expression and activity is ...
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(2009-03-03)Department: Cancer BiologyGastric adenocarcinoma is strongly associated with the presence of H. pylori, and both microbial and host factors influence the risk for carcinogenesis. A novel role for H. pylori in the stimulation of the p120ctn/Kaiso ...
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(2021-09-17)Department: Cancer BiologyHypoxia is a common feature in tumors and induces signaling that promotes tumor cell survival, invasion, and metastasis. Questions remain, however, about the role of HIF signaling in tumor cell dissemination to bone and ...
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(2016-04-04)Department: Cancer BiologySalivary adenoid cystic carcinoma (ACC) is prone to perineural invasion, late recurrence, and distal metastases, with 20-year survival of only 10%. Research defining new targets in ACC has lagged largely due to a dearth ...
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(2015-07-21)Department: Cancer BiologyCancer is the second leading cause of death in the United States. It is important to identify novel drivers of cancer in order to understand these diseases so we can improve patient prognosis. This dissertation focuses ...
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(2015-03-06)Department: Cancer BiologySolid tumor treatment paradigms have drastically improved in recent decades through direct targeting of the protein products of somatic, constitutively active “driver” mutations and their effector signaling pathways. Prior ...
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(2010-04-17)Department: Cancer BiologyThis research project is to identify FoxA1 interacting partners. In this study, a potential FoxA1 binding partner, Upstream Stimulatory Factor 2 (USF2), has been examined; its DNA binding activity was determined and the ...
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(2024-03-21)Department: Cancer BiologyLiquid biopsy is a promising technique that is already impacting clinical decision making by supplementing traditional tumor biopsy as a way to derive molecular information about various cancers. However, it has potential ...
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(2017-07-31)Department: Cancer BiologyThe skeleton is a common site for breast cancer metastasis. Although significant progress has been made to manage osteolytic bone lesions caused by breast tumors, patients still die of the disease, and the current treatments ...
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(2022-05-16)Department: Cancer BiologyLung adenocarcinoma (LUAD) is a heterogeneous group of tumors associated with different survival rates, even when detected at an early stage. While screening programs have proven to significantly increase the chance of ...
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(2016-02-19)Department: Cancer BiologyNuclear factor κ-light chain enhancer of activated B cells (NF-κB) is a transcription factor that can be activated through canonical or non-canonical signaling pathways, and activation of both pathways has been observed ...
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(2007-07-30)Department: Cancer BiologyKaposi's sarcoma Herpesvirus (KSHV) is the causative agent of Kaposi's sarcoma, primary effusion lymphoma (PEL) and multicentric Castlemen's disease (MCD). This ƒ×-herpesvirus infects endothelial cells lining the vascular ...
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(2019-03-29)Department: Cancer BiologyDespite the high prevalence of breast cancer metastasis to bone, there are currently no therapeutic options to cure metastatic disease. This deficit is in part due to the lack in vivo models that recapitulate prolonged ...
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(2022-07-13)Department: Cancer BiologyIntegrins, the principal extracellular matrix (ECM) receptors of the cell, promote cell adhesion, migration, and proliferation, which are key events for cancer growth and metastasis. To date, most integrin-targeted cancer ...
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(2013-12-03)Department: Cancer BiologyInactivation of STK11/LKB1 is one of the most common genetic events in lung cancer, and understanding the cellular phenotypes and molecular pathways altered as a consequence will aid the development of therapeutic strategies ...
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(2012-04-24)Department: Cancer BiologyInactivating mutations in TGF-©¬ receptors and Smad signal transducers that contribute to resistance to TGF-©¬, are associated with only very small number of NSCLC. The Smad dependent pathway is involved in the tumor ...