Browsing Electronic Theses and Dissertations by Department "Chemistry"
Now showing items 341-360 of 363
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(2024-03-19)Department: ChemistryAs nanochemistry grows as a field and the applications of nanomaterials emerge, the importance of understanding what happens in the reaction flask during synthesis—thinking smaller than the nanoscale level to the molecular ...
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(2024-03-21)Department: ChemistryThe roots of the central African iboga shrub (Tabernanthe iboga) induce a hallucinogenic response that has been used for centuries in the Bwiti religion in West Central Africa. The alkaloids contained in this root are ...
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(2019-06-17)Department: ChemistryI. Prostaglandin E2 (PGE2) is a cyclic, oxygenated metabolite of arachidonic acid that has been shown to play a role in the pathophysiology of many diseases including arthritis, cardiovascular disease, breast cancer, ...
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(2010-09-28)Department: ChemistryThis dissertation describes advances in total synthesis, synthetic methodology, and chemical biology. The total synthesis and stereochemical revision of Ciliatamides A-C will be discussed in detail. Also, the total ...
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(2020-05-14)Department: ChemistryAntibiotic resistance is now known for every clinically prescribed antibiotic, which means new antibiotics with novel mechanisms of action are needed. Historically natural products have served as a source of new antimicrobial ...
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(2013-03-01)Department: ChemistryComplex secondary metabolites from diverse life forms play key roles in mediating many biological processes but the exact nature of their function is often unknown. Chemical synthesis can be utilized to access such compounds ...
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(2022-01-18)Department: ChemistryNatural product total synthesis provides efficient access to privileged scaffolds with unique biological activities. Herein, we describe our efforts in the synthesis of three peptidic natural products: coelichelin, cochinmicin ...
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(2010-04-08)Department: ChemistryMarine natural products have attracted the attention of chemists and biologists across the world for over the past five decades. The fascinating array of marine secondary metabolites has resulted in extensive examination ...
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(2021-09-27)Department: ChemistryPulmonary arterial hypertension (PAH) is a fatal vascular disease within the lungs characterized by oxidative stress and endothelial cell proliferation. Associated with this oxidative injury is the increased production ...
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(2019-08-30)Department: ChemistryZwitterionic polysaccharides (ZPS) activate T-cell-dependent immune responses by major histocompatibility complex class II presentation. Herein, we detail a review of the field of ZPSs and report the first synthesis of a ...
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(2016-10-26)Department: ChemistryUnnatural amino acid derived fragments are present in a multitude of pharmaceuticals and biologically relevant molecules including complex peptides. Current preparative methods focus almost entirely on the enantioselective ...
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(2018-09-27)Department: ChemistryASCT-2 is an evolutionary redundant neutral amino acid transporter protein that has been consistently reported as being expressed at elevated levels in high profile malignant diseases, such as breast, lung, and gastrointestinal ...
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(2015-11-30)Department: Chemistry2-Amino-3-methylimidizo-[4,5-ʄ]-quinoline (IQ), a potent dietary mutagen, forms DNA adducts at the N² and C8-positions of 2ʹ-deoxyguanosine. IQ induces G to A transitions and G to T transversions in eukaryotic cells. The ...
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(2006-09-05)Department: ChemistryTrimethylsilylated allyl ligands allow for the synthesis of thermally stable allyl complexes with metals throughout the periodic table. In this work, bulky allyl ligands were used in the synthesis of complexes with early ...
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(2020-03-31)Department: ChemistryColloid quantum dots (QDs) are semiconductor nanocrystals that can be tuned to emit specific wavelengths of light based upon their size. Maintaining long-term brightness of QDs is crucial towards their applications. Achieving ...
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(2010-01-21)Department: ChemistryDue to the declining availability of fossil-fuels and the adverse environmental affects of the same, the world has begun a move to more efficient and longer-lasting solid-state lighting. Ultrasmall CdSe nanocrystals ...
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(2021-03-06)Department: ChemistryUmpolung amide synthesis (UmAS) exploits the unique properties of an α-halo nitroalkane in its reaction with an amine to produce an amide. The “umpolung” moniker reflects its paradigm-breaking C–N bond formation on the ...
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(2014-07-22)Department: ChemistryTraditional amide synthesis employs a nucleophilic amine, which is reacted with an electrophilic activated carboxylic acid or carboxylic acid surrogate. Recently, colleagues in the Johnston lab introduced an unconventional ...
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(2012-12-03)Department: ChemistryUMPOLUNG AMIDE SYNTHESIS: APPLICATIONS IN ENANTIOSELECTIVE PEPTIDE SYNTHESISDAWN M. MAKLEYDissertation under the direction of Professor Jeffrey N. JohnstonThe development and application of the novel Umpolung Amide Synthesis ...
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(2023-03-27)Department: ChemistryIndium phosphide quantum dots (QDs) are semiconductor nanocrystals who’s tunable photophysical properties makes them useful as emitters in a wide array of applications, including solid state lighting, lasing, bioimaging, ...