Browsing Electronic Theses and Dissertations by Department "Chemistry"
Now showing items 281-300 of 363
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(2008-06-06)Department: ChemistryThis dissertation involves the structural and equilibrium studies of three DNA lesions: aflatoxin B1 formamidopyrimidine, methyl formamidopyrimidine, and thymine glycol. Studies of the methyl formamidopyrimidine ...
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(2012-02-21)Department: ChemistryThe inducible enzyme microsomal prostaglandin E synthase 1 (MPGES1) is a glutathione-dependent prostaglandin H2 isomerase that has been implicated in a variety of inflammatory diseases and several forms of cancer. While ...
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(2016-03-25)Department: ChemistryN6-(Deoxy-D-Erythro-Pentofuranosyl)-2,6-Diamino-3,4-Dihydro-4-Oxo-5-N-Methylformamido-Pyrimidine (MeFapy-dG) is a deoxyribonucleic acid lesion that has been hypothesized to be induced by methylating chemotherapeutic agents. ...
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(2012-12-17)Department: ChemistryTo examine the effect of major groove electrostatics on the stability and structure of DNA, in the first portion of this dissertation a detailed structural characterization of the 7-deaza-2'-deoxyadenosine:dT base pair in ...
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(2014-12-24)Department: ChemistryN6-(Deoxy-d-erythro-pentofuranosyl)-2,6-diamino-3,4-dihydro-4-oxo-5-N-methylformamidopyrimidine (MeFapy-dG) is the methylated and persistent ring opened product of the common N7 alkylation site of guanines in DNA, formed ...
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(2018-03-24)Department: ChemistryHelical membrane proteins (HMPs) play essential roles in various biological processes. Despite their prevalence in the genome, a very small portion (~2%) of structures in the Protein Data Bank are HMPs, partially due to ...
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(2016-07-08)Department: ChemistryStructure, substrate selectivity, and catalytic mechanism of the fosfomycin resistance enzyme, FosB, from Gram-positive pathogens By: Mary E. Keithly Fosfomycin, a broad spectrum antibiotic, is used clinically to treat ...
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(2005-07-15)Department: ChemistryCHEMISTRY STUDIES OF A GENOMIC FOSFOMYCIN RESISTANCE PROTEIN FROM PSEUDOMONAS AERUGINOSA RACHEL PHARRIS RIGSBY Dissertation under the direction of Professor Richard N. Armstrong In the last two decades it has become ...
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(2017-05-26)Department: ChemistryLipids are loosely defined as a group of naturally occurring organic compounds which are hydrophobic or amphipathic in nature, but which are also readily soluble in organic solvents. These solubility features are present ...
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Studies on graphitic carbon nanofibers: towards electronic, mechanical and biological applications (2006-07-13)Department: ChemistryGraphitic carbon nanofibers (GCNFs) have become the subject of extensive research due to their high aspect ratio, large surface area, superior electronic and mechanical properties. A variety of nanocomposites containing ...
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(2017-08-22)Department: ChemistryThe fully glycosylated apoptolidins have been shown to exert nanomolar activity against several cancer cell types (e.g. human lung cancer and glioblastoma cells). This activity is directly correlated with glycosylation ...
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(2016-07-27)Department: ChemistryHuman milk oligosaccharides (HMOs) are a diverse class of carbohydrates that are unique to human milk. These oligosaccharides have been demonstrated to influence infant health through several mechanisms including helping ...
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(2010-12-04)Department: ChemistryThe dissertation contained herein describes the synthetic efforts toward the total synthesis of the furanocembrane bielschowskysin, and comprises five generations of synthetic strategies. Bielschowskysin was isolated in ...
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(2011-10-20)Department: ChemistryThe diazoparaquinone natural products lomaiviticin A and lomaiviticin B were isolated in 2001 from the marine actinomycete bacteria Micromonospora lomaivitiensis. Lomaiviticin A showed potent DNA-damaging and antibacterial ...
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(2012-12-21)Department: ChemistryThe hibarimicin family of natural products was isolated in 1995 from the culture broth of the rare actinomycete Microbispora rosea subsp. hibaria TP-A0121. This complex polyketide type II family exhibits strong inhibition ...
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(2024-03-22)Department: ChemistryChiroptical spectroscopy relies on the differential interaction of left- and right-circularly polarized light with chiral molecules. Chiral molecules are ubiquitous in nature and chemistry, and thus the elucidation of their ...
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(2010-04-27)Department: ChemistryA quarter century ago, there began an explosion of research into materials on the nanoscale regime. This progress was made possible with the advance of techniques for production of things with nanoscale dimensions and with ...
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(2014-04-08)Department: ChemistrySubstrate-selective Inhibition of Cyclooxygenase-2: Molecular Determinants, Probe Development, and In Vivo Effects. Daniel John Hermanson Dissertation under the direction of Professor Lawrence J. Marnett Cyclooxygenase-2 ...
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(2017-08-24)Department: ChemistryCompound metal nanoparticles have a large surface area-to-volume ratio, a high concentration of low coordination sites, and surface vacancies that give rise to properties favorable for heterogeneous catalytic processes. ...
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(2007-12-18)Department: ChemistryDevelopment of a methodology for an efficient multi-gram scale preparation of 2-amino-5-pyridinols and subsequent investigation of the antioxidant properties of these compounds were executed. The key compound, 2-amino-3, ...