Browsing Electronic Theses and Dissertations by Department "Chemistry"
Now showing items 261-280 of 363
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Stereodivergent Approach to the Total Synthesis of Selected syn trans and anti trans ∆13-9-isofurans (2022-07-09)Department: ChemistryPulmonary arterial hypertension (PAH) is a fatal vascular disease within the lungs marked by oxidative stress and endothelial cell proliferation. The free radicals generated under oxidative stress conditions initiate the ...
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(2012-07-17)Department: ChemistryThis dissertation is concerned with the stereospecific transformations of α-amino-β-diazonium intermediates. The mechanism of the Brønsted acid-catalyzed aza-Darzens reaction is explored by charting the stereochemical ...
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(2010-08-11)Department: ChemistryThe effects of adding steric bulk to the ligands of main group organometallic complexes are examined in this dissertation. First, bulky allyl complexes of beryllium and magnesium, using the 1,3-bis(trimethylsilyl)allyl ...
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(2018-03-26)Department: ChemistryInfectious diseases claim tens of millions of lives globally each year and greatly impact the quality of life of many others. Low- and middle-income countries bear the vast majority of the global burden of infectious disease ...
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(2020-08-31)Department: ChemistryOne major challenge within biomedical research is the ability to identify unknown analytes in untargeted experiments. The aim of this work is to address this challenge using ion mobility – mass spectrometry (IM-MS). ...
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(2015-05-22)Department: ChemistryStructural ion mobility-mass spectrometry (IM-MS) is often paired with computational conformational space studies to provide more insight into the experimental measurements. From the IM-MS or gas phase electrophoresis ...
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(2022-11-08)Department: ChemistryLateral flow assays (LFAs) are the most common form of a rapid diagnostic test, and their use has become critical for public health surveillance. These immunoassays allow for quick time-to-result and allow for users to ...
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(2022-11-08)Department: ChemistryLateral flow assays (LFAs) are the most common form of a rapid diagnostic test, and their use has become critical for public health surveillance. These immunoassays allow for quick time-to-result and allow for users to ...
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(2017-03-31)Department: ChemistryPoint-of-care diagnostics for malaria currently rely on antibody-based rapid diagnostic tests (RDTs), but these tests are in danger of becoming obsolete as the world moves to eliminate malaria. More sensitive and robust ...
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(2017-03-29)Department: ChemistryMaintaining the integrity of the genome is critical for the survival of all organisms. Genome maintenance must be efficient because we are constantly under exposure to genotoxic agents including UV-light, endogenous and ...
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(2024-03-22)Department: ChemistryCystic fibrosis (CF) is a lethal genetic disease caused by mutations in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), an epithelial anion channel protein. CFTR variants disrupt CFTR protein folding, leading ...
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(2024-03-22)Department: ChemistryCystic fibrosis (CF) is a lethal genetic disease caused by mutations in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), an epithelial anion channel protein. CFTR variants disrupt CFTR protein folding, leading ...
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(2024-03-22)Department: ChemistryCystic fibrosis (CF) is a lethal genetic disease caused by mutations in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), an epithelial anion channel protein. CFTR variants disrupt CFTR protein folding, leading ...
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(2011-04-15)Department: ChemistryThe characterization of monolayer-protected metal nanoparticles (NPs) is crucial to the advancement of biological, optical, and electronic applications. However, full characterization requires time and expertise with a ...
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(2016-08-03)Department: ChemistryDamage to DNA results from many endogenous and exogenous sources and plays a significant role in cancer etiology. 3-Nitrobenzathrone (3-NBA) is a component of diesel exhaust that is known to form DNA adducts. Aminobenzanthrone ...
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(2020-05-19)Department: ChemistryDNA, a crucial biomolecule, can undergo damage from both exogenous and endogenous sources. Examples of common DNA damage products include abasic sites (AP sites), thymine glycol, and 8-oxoguanine. These DNA damage products ...
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(2009-07-25)Department: ChemistryButadiene monoepoxide (BDO) is the major metabolite of butadiene (BD), a widely used petrochemical and known human and animal carcinogen. BD metabolites may be involved in BD-induced carcinogenicity primarily through the ...
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(2023-03-22)Department: ChemistryTheoretical modeling workflows have been established in the McLean lab to support Ion mobility-mass spectrometry (IM-MS) investigations and expanded for the structural analysis of non-covalent small molecule complexes. The ...
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(2012-12-17)Department: ChemistrySystems biology seeks to describe the function of a biological system using a holistic, multiscale approach. This approach encompasses the analyses of molecular classes such as the genome, transcriptome, proteome, and ...
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(2008-12-01)Department: ChemistryThis dissertation involved the structural investigations of butadiene-derived N6,N6-deoxycytosine intrastrand cross-linked adduct and N3-deoxyuridine adducts in DNA by NMR or X-ray crystallography, respectively. Solution ...