Browsing Electronic Theses and Dissertations by Title
Now showing items 2442-2461 of 6988
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(2017-11-21)Department: Biomedical InformaticsThe reduced cost of sequencing has made it feasible to acquire multi-tissue site expression data from the same patient. In the field of cancer research, this has caused an accumulation of cancer type specific tumor with ...
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(2019-01-18)Department: BiochemistryType II topoisomerases are enzymes that transiently cut the DNA to regulate supercoiling and remove knots and tangles from the genome. Although they are essential for cell survivability, these enzymes are potentially ...
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(2016-11-21)Department: Biomedical EngineeringAlthough siRNA-based therapeutics hold great promise for systemic cancer treatment, polyplex nanocarrier systems face many intravenous challenges that limit their pharmacokinetic potential and therefore reduce tumor ...
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(2022-03-17)Department: Cell & Developmental BiologyRhabdoid tumors (RT) are rare and deadly pediatric cancers driven by loss of SMARCB1, which encodes the SNF5 component of the SWI/SNF chromatin remodeler. Loss of SMARCB1 is associated with a complex set of phenotypic ...
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(2010-04-12)Department: NeuroscienceFor two principle reasons, the transmembrane Met receptor tyrosine kinase has emerged as an important molecular target for study in the developing forebrain: 1) it regulates a variety of neurodevelopmental processes in ...
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(2020-01-16)Department: Biomedical EngineeringAortic valve disease, including developmental defects and late-stage fibrocalcific remodeling, is a major global health burden. There is no pharmaceutical treatment for valve disease, and options for valve replacement are ...
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(2011-08-11)Department: NeuroscienceThe Met receptor tyrosine kinase is capable of mediating several neurodevelopmental events in vitro, but its functions in vivo are incompletely understood. Three alleles in the 5’ regulatory region of the human ortholog, ...
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(2004-04-08)Department: Cell and Developmental BiologyThe ubiquitin-proteasome pathway (UPP) is the principal mechanism for the selective degradation of short-lived proteins. The proximal signal for UPP-mediated proteolysis is the covalent modification of target proteins with ...
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(2006-12-01)Department: Cell and Developmental BiologyAnimal movement is controlled by the motor circuit, which features an axial nerve cord where motor neurons transmit signals from the brain to specific muscles. The development of this circuit depends on differential gene ...
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Expressive language intratest scatter and attention problems of preschool-age children who stutter (2012-10-15)Department: Hearing and Speech SciencesPurpose: The purpose of this study was to assess attention problems and intratest scatter (variability) of responses to standardized tests of expressive language by preschool-age children who do (CWS) and do not stutter ...
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(2012-01-25)Department: Molecular Physiology and BiophysicsThis project and the experiments discussed in this document sought to contribute a functional basis for SNPs within G6PC2 significantly associated with variations in fasting blood glucose by genome-wide association study. ...
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(2008-07-26)Department: Leadership and Policy StudiesThe growth of part-time and off tenure track full time faculty employment since 1970s has been paralleled by the increasing literature on the subject. Many of the studies remained descriptive in nature and focused on the ...
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(2019-07-22)Department: Political ScienceA central tenet in the electoral systems subfield is that parties and their members pursue opportunities to advance partisan objectives via the strategic adoption of electoral rules. This scholarly consensus exists for ...
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(2019-02-18)Department: Molecular Physiology and BiophysicsEpidemiological studies have demonstrated an inverse correlation between high-density lipoproteins (HDL) cholesterol and cardiovascular disease (CVD) risk; however therapeutic approaches aimed at raising HDL cholesterol ...
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(2021-03-25)Department: Biological SciencesExtracellular vesicles (EVs) are mediators of cell-cell communication and play important roles in many physiological processes including cancer and drug resistance. EVs are nanosized particles secreted from every cell, ...
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(2017-08-09)Department: Biomedical InformaticsLung cancer is the leading cause of cancer-related death in the United States and worldwide. Natural language processing (NLP) tools exist to determine smoking status (ever-smoker vs. never-smoker) from electronic health ...
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(2004-04-13)Department: Electrical EngineeringThis dissertation presents a method to extract features salient to a mobile robot navigation task in a specific environment. The extraction process is bootstrapped by a human operator’s tele-operation and is based on the ...
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(2012-08-14)Department: ReligionEver since rumors of a “Golden Bible” began circulating in the late 1820s, the Book of Mormon has occupied a singular place in the American popular imagination. It has been revered as scripture by Latter-day Saints and ...
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(2023-03-24)Department: Computer SciencePurpose: Surgical skill assessment is essential for safe operations. In endoscopic kidney stone surgery, surgeons must perform a highly skill-dependent mental mapping from the pre-operative scan to the intraoperative ...
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(2009-04-02)Department: PsychologyThough it is a common occurrence during activities such as team sports to have to attend to multiple objects at once, we are only able to direct gaze to one location at a time. Where will gaze be directed when there are ...