Browsing Electronic Theses and Dissertations by Department "Chemistry"
Now showing items 241-260 of 363
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(2021-01-05)Department: ChemistryRacial disparities in Alzheimer’s disease (AD) is less recognized, specifically among African American/Black adults. Primary manifestations of AD are similar for everyone irrespective of race when considering Aβ plaques ...
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(2021-08-04)Department: ChemistryAlzheimer’s disease (AD) disproportionately affects African American/Black adults, leading to disparities in relation to non-Hispanic White adults. Though many factors such as socioeconomic factors and comorbidities are ...
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(2017-03-03)Department: ChemistryVaccines are one of the greatest public health successes; yet there is an incomplete understanding of which genes and proteins are induced by vaccines and how they contribute to the development of protective immune responses. ...
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(2008-08-13)Department: ChemistryThe primary aim of this research was to incorporate highly fluorescent semiconductor nanocrystals, or quantum dots (QDs), in various biological assays as an improved means of optically imaging membrane associated receptors. ...
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(2007-12-13)Department: ChemistryProtein identification generally involves enzymatic digestion of proteins followed by mass spectrometry (MS) sequencing analysis of the resulting peptides, a process referred to as bottom-up proteomics. Another approach ...
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(2018-03-28)Department: ChemistryFungal cyclooligomeric depsipeptides (CODs) are structurally privileged natural products as demonstrated by their broad spectrum of biological activities, including antibiotic, insecticidal, and antitumor activities. In ...
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(2018-09-24)Department: ChemistrySolar energy stands out as an extremely promising candidate to meet the need for renewable energy due to its abundance in availability and the capability of application in multiple scenarios. This work aims to push the ...
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(2015-12-02)Department: ChemistryUsing density functional theory (DFT) the interface of metal nanoparticles to cup-stacked carbon nanofibers were modelled and studied for binding interactions and characterization signatures for different crystal facets ...
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(2022-07-14)Department: ChemistryMatrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) allows for untargeted spatial investigation of complex biological systems, such as tissue sections. Confident analyte identification is ...
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(2016-03-28)Department: ChemistryAs climate change and population growth increase the demand for energy and clean water, research must be to alleviate the increased pressure on the energy-water nexus. In this work, two potential solutions to this problem ...
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(2011-04-13)Department: ChemistryThe purpose of the dissertation is to develop whole cell electron microscopy (EM) techniques capable of imaging tagged proteins. The utility of lanthanide chelate molecules as membrane penetrating bimodal fluorescent and ...
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(2021-03-11)Department: ChemistryCatalysts capable of heterolytic silane activation have been utilized for the conversion of alkyl ethers to silyl ethers via C-O bond cleavage. Previously reported systems for this transformation show poor selectivity. In ...
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(2018-04-09)Department: ChemistryOligosaccharides and glycoconjugates are important for understanding biological functions. A major obstacle in glycobiology and glycomedicine is the limited availability of structurally-defined, homogeneous oligosaccharides ...
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(2014-11-06)Department: ChemistryAflatoxin B1 (AFB1), a mycotoxin produced by Aspergillus flavus, is oxidized by cytochrome P450 enzymes to aflatoxin B1-8,9-epoxide, which alkylates DNA at N7-dG. Under basic conditions, this N7-dG adduct rearranges to ...
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(2011-03-11)Department: ChemistryThis project involves the characterization of ultrasmall white light-emitting CdSe nanocrystals and the development of new synthetic techniques for magic-sized CdSe and CdTe nanocrystals. The nature of the broad emission ...
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(2020-03-31)Department: ChemistryThe dopamine transporter (DAT) protein determines strength and duration of neurotransmission by dopamine reuptake from extracellular space into presynaptic nerve cells. Variation of the DAT gene (DAT1, SLC6A3) has been ...
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(2013-04-30)Department: ChemistryThe presynaptic serotonin (5-HT) transporter (SERT) is targeted by widely prescribed antidepressant medications. Altered SERT expression or regulation has been implicated in multiple neuropsychiatric disorders, including ...
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(2016-07-22)Department: ChemistryThe CaMKII enzyme is involved in diverse biological processes including control of heart rate and synaptic plasticity. CaMKII is activated by binding of calmodulin (CaM) and ATP. Its intricate structure and dynamics are ...
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(2009-06-10)Department: ChemistryThis work focuses on bis(indenyl) complexes of vanadium, chromium, manganese and iron. Specifically, spin-state manipulations of the complexes were attempted by the variation of ligand substituents in number, type, and ...
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(2020-06-19)Department: ChemistryThis dissertation describes (i) advances in the stereoselective synthesis of β-fluoroamines, (ii) manipulation of ring closing metathesis conditions to access several carbocyclic rings displaying β-fluoroamines, (iii) the ...