Browsing Electronic Theses and Dissertations by Department "Pathology"
Now showing items 21-40 of 44
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(2012-07-26)Department: PathologyCoordination of viral replication requires successful and often complex interactions of viral proteins and cellular factors. Although much progress has been made in understanding the formation of specialized sites of ...
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(2013-07-30)Department: PathologyRecently our lab has demonstrated that clustering of the tetraspanin CD151 on the surface of tumor cells is capable of inhibiting cell migration and cancer metastasis. As a member of the tetraspanin superfamily CD151 ...
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(2011-12-12)Department: PathologyIn this dissertation, I examined the function of the alpha2beta1 integrin in epithelial tumor cells as well as in the tumor microenvironment. The alpha2beta1 integrin is a surface heterodimeric receptor found on epithelial, ...
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(2018-04-11)Department: PathologyThe family of ribosomal S6 Ser/Thr protein kinases (RSK) controls proliferation, viability and motility and, therefore, contributes to the etiology of numerous cancers, including breast. We found that RSK2 is an obligate ...
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(2005-09-09)Department: PathologyBifunctional alkylating agents that cause DNA cross-linking are implicated in the pathogenesis of myelodysplastic syndrome (MDS) and MDS related acute myeloid leukemia (MDR-AML). Therefore, characterizing hematopoietic ...
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(2011-02-25)Department: PathologyCellular adhesions to the extracellular matrix (ECM) and to neighboring cells are vital interactions within metazoans. This dissertation examines cellular adhesion by utilizing the adhesive interaction between platelets ...
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(2010-09-06)Department: PathologyThe work in this thesis involves characterization of a novel Streptococcus agalactiae-secreted protein, skizzle, and its interactions with key proteins of the human fibrinolytic system. Skizzle binds human plasminogen ...
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(2009-04-02)Department: PathologyAtherosclerosis is a chronic vascular disease which is the underlying cause of over half the deaths in the United States each year. Variations in local vascular hemodynamics predispose select sites in the vasculature to ...
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(2008-12-01)Department: PathologyThe focus of this project is determining if an ankyrin-G-dependent pathway controls the membrnae expression of the voltage-gated sodium channel 1.5 in cardiomyocytes. Disruption of the normal localization of Nav1.5 can ...
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(2015-07-21)Department: PathologyRSK is a family of four Ser/Thr protein kinases activated by ERK1/2 signaling. RSK is often misregulated in a variety of cancers, including breast and prostate. More recently, RSK1 and RSK2 have been shown to promote ...
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(2015-11-13)Department: PathologymicroRNA (miRNA) are critical mediators of cellular signaling and regulate most biological processes. Thus, it is not surprising that miRNA dysregulation significantly contributes to tumorigenesis. In this dissertation, I ...
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(2009-07-28)Department: PathologyMacrophage foam cells are prominent in atherosclerotic lesions. In late stage disease, much of the cholesterol accumulation within foam cells is found in large, swollen, lysosomes. Tissue culture models using human macrophages ...
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(2014-07-22)Department: PathologyAlthough the MYC transcription factor was discovered over three decades ago and is dysregulated in the majority of human cancers, its regulation remains incompletely understood and there is no pharmacologic means to inhibit ...
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(2013-04-01)Department: PathologySystemic lupus erythematosus (SLE) patients are at increased risk of developing components of the metabolic syndrome. Furthermore, obesity and high-fat diet (HFD) can lead to SLE nephritis exacerbation in humans and mouse ...
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(2009-04-09)Department: PathologyActivation of coagulation factor IX is a pivotal reaction in the formation and maintenance of a fibrin clot. Factor IX is activated by two structurally unrelated enzymes; factor XIa of the intrinsic coagulation cascade and ...
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(2005-01-07)Department: PathologyThe development of atherosclerosis can be influenced by genetic or pharmacologic disruptions of cellular cholesterol homeostasis. Cholesterol homeostasis in macrophages is of critical importance because these cells have a ...
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(2018-07-26)Department: PathologyGenome maintenance is essential for the viability of eukaryotic cells and for the prevention of tumorigenesis. DNA replication stress is a significant contributor to genomic instability. As such, cells employ a complex ...
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(2016-11-21)Department: PathologySepsis is a systemic inflammatory response to infection. It is often accompanied by the pathologic production of thrombin, the key enzyme in blood plasma responsible for coagulation, and by contact activation, which is a ...
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(2015-03-24)Department: PathologyInvariant natural killer T (iNKT) cells are unique group of lymphocytes that secrete copious amounts of immunoregulatory cytokines upon activation. This allows iNKT cells to modulate a wide range of mouse models that model ...
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(2012-04-11)Department: PathologyThis goal of this dissertation was to investigate the molecular mechanisms of prostate tumorigenesis initiated by loss of the tumor suppressor NKX3.1. In human prostate cancer, NKX3.1 is lost during disease progression. ...