Browsing Electronic Theses and Dissertations by Department "Cell & Developmental Biology"
Now showing items 21-40 of 55
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(2022-02-16)Department: Cell & Developmental BiologyThe brain is one of the most complex and mysterious organs in the human body. Centuries of research have shown that it is generated by a finely orchestrated series of events that take place in the first weeks of life up ...
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(2022-03-17)Department: Cell & Developmental BiologyRhabdoid tumors (RT) are rare and deadly pediatric cancers driven by loss of SMARCB1, which encodes the SNF5 component of the SWI/SNF chromatin remodeler. Loss of SMARCB1 is associated with a complex set of phenotypic ...
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(2023-03-29)Department: Cell & Developmental BiologyIn pancreatic beta cells, molecular motors use cytoskeletal polymers microtubules as tracks for intracellular transport of secretory insulin granules. Beta-cell microtubule network has a complex architecture, which allows ...
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(2021-01-06)Department: Cell & Developmental BiologyEpithelial cells possess intrinsic mechanisms to maintain an appropriate cell density for normal tissue morphogenesis and homeostasis. Defects in such mechanisms likely contribute to hyperplasia and cancer initiation. To ...
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(2021-05-13)Department: Cell & Developmental BiologyThe body of work presented in this dissertation details the characterization of a novel human-cell derived model of the understudied, non-canonical cullin scaffold CUL9. Unlike other cullins, previous efforts to characterize ...
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(2023-07-18)Department: Cell & Developmental BiologyEye development is a delicate process requiring a balance of genes and proteins expressed over the correct time course. Disruptions in the expression of essential genes are detrimental to vision. The transcription factor ...
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(2024-01-30)Department: Cell & Developmental BiologyGastric cancer presents a significant global health challenge. This thesis explores the interplay of intrinsic and extrinsic factors driving gastric metaplasia, a precursor to gastric cancer. It particularly focuses on the ...
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(2020-06-16)Department: Cell & Developmental BiologyHuman casein kinase 1 delta (CK1δ) and epsilon (CK1ε) are members of a conserved family of ubiquitously expressed serine/threonine kinases that regulate multiple cellular processes including endocytosis, circadian rhythm, ...
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(2022-03-29)Department: Cell & Developmental BiologyThe microtubule network in cells continuously remodels to facilitate its vital functions in cell division, cell motility and intracellular transport. Organization of the microtubule network is enabled by regulation of the ...
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(2024-03-18)Department: Cell & Developmental BiologyTuberous sclerosis complex (TSC) is a multi-organ genetic disorder caused by mutations in either TSC1 or TSC2 which encode hamartin and tuberin, respectively. Hamartin and tuberin form a protein complex that indirectly, ...
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(2024-03-18)Department: Cell & Developmental BiologyTuberous sclerosis complex (TSC) is a multi-organ genetic disorder caused by mutations in either TSC1 or TSC2 which encode hamartin and tuberin, respectively. Hamartin and tuberin form a protein complex that indirectly, ...
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(2023-11-16)Department: Cell & Developmental BiologyActin-based protrusions are found on the surface of all eukaryotic cells, where they support diverse biological activities essential for life. Models of protrusion growth hypothesize that actin filament assembly provides ...
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(2023-11-21)Department: Cell & Developmental BiologyThe retinal pigment epithelium (RPE) is a monolayer of pigmented cuboidal cells that separates the retina from the choroid and is crucial for vision. Defective RPE function and RPE atrophy can often cause age-related macular ...
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(2023-03-29)Department: Cell & Developmental BiologyCELL AND DEVELOPMENTAL BIOLOGY Mechanisms of Diabetic Cardiomyopathy Cassandra Awgulewitsch Dissertation under the direction of Associate Professor Antonis K. Hatzopoulos Type 2 Diabetes (T2D) is a prominent risk factor ...
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(2023-05-24)Department: Cell & Developmental BiologyMany questions remain unanswered about the processes controlling epithelial development and homeostasis in the mammary gland. The monolayer luminal epithelium is generated from multilayered cells within the terminal end ...
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(2021-02-04)Department: Cell & Developmental BiologyCytokinesis is the final step in cell division in which two daughter cells physically separate. In order to complete this process, many eukaryotes, including Schizosaccharomyces pombe, assemble an actin- and myosin-based ...
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(2020-05-14)Department: Cell & Developmental BiologyAlternating hemiplegia of childhood (AHC) is a rare and devastating neurodevelopmental disorder caused by de novo heterozygous missense mutations in ATP1A3, a crucial gene encoding the 3 subunit of the Na,K-ATPase (NKA) ...
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(2021-09-20)Department: Cell & Developmental BiologyThe heart is an essential organ that facilitates blood flow throughout the body, transporting oxygenated blood from the lungs to the body and in transporting deoxygenated blood from the body to the lungs. Behind each beat ...
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(2022-11-17)Department: Cell & Developmental BiologyThe overarching goal of my thesis work is to better understand the transcriptional regulation and functions of Sox17 during early development. To start unveiling the complex molecular mechanisms that modulate Sox17 expression, ...
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(2023-03-13)Department: Cell & Developmental BiologyGlucose transporters are principal gatekeepers of cellular glucose metabolism. Understanding mechanisms that regulate their activity, trafficking, and degradation can provide insight into physiological regulation of glucose ...