Browsing Electronic Theses and Dissertations by Department "Chemistry"
Now showing items 161-180 of 363
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(2018-08-06)Department: ChemistryProtein-small molecule structure prediction, or protein-ligand docking, is a computational method for modeling how binding partners will interaction on an atomic level. Accurate prediction of protein-small molecule ...
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(2018-01-17)Department: ChemistryDetermination of a protein’s structural equilibrium constitution remains a challenge. Experimental techniques like X-ray crystallography or nuclear magnetic resonance spectroscopy either are only able to determine single ...
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(2024-01-18)Department: ChemistryMALDI IMS is a powerful technology that combines multiplexed omics data with in situ spatial information. Additional pairing with compatible imaging modalities increases the biological context of the biomolecular distributions ...
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(2008-12-15)Department: ChemistryExposure to endogenous and exogenous chemicals can lead to modification of DNA and potentially lead to cancer. Frameshift mutations may be a consequence of these modifications to DNA. Oligonucleotides were synthesized ...
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(2008-12-31)Department: ChemistryIndomethacin (INDO) has been a commercially available non-steroidal anti-inflammatory drug since 1963. As such, INDO has well-defined toxicology and pharmacokinetics that allow it to serve as a known molecular scaffold ...
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(2014-07-25)Department: ChemistryPhotosystem I is a photoactive membrane protein found in higher plants, some algae, and cyanobacteria. It is part of the solar energy conversion mechanism that fuels most life on the planet. It has been shown that photocurrents ...
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INTERFACING PHOTOSYSTEM I WITH CONDUCTIVE THREE-DIMENSIONAL FRAMEWORKS FOR SOLAR ENERGY CONVERSION (2020-10-12)Department: ChemistryPhotosystem I complex serves not only as a model for inspiration but also as a complete entity which can be extracted and integrated directly into alternative energy technologies. When creating PSI-based solar energy ...
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(2009-12-07)Department: ChemistryBackscattering interferometry (BSI) is a relatively new technique used to study molecular interactions in a label-free format and is proving to be a versatile biosensing technique. BSI quantifies minute changes in refractive ...
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Investigating Biochemical Interactions Relevant To Human Health Using Backscattering Interferometry (2013-07-17)Department: ChemistryThis project is concerned with the characterization of biomolecular interactions that are pertinent to human health using backscattering interferometry (BSI). In this dissertation, I used the unique ability of BSI to ...
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(2017-08-28)Department: ChemistryIodolactonization is a venerable chemical reaction with considerable utility in the synthesis of organic compounds. More recently, enantioselective methods reliant upon organocatalysts have been developed. This work details ...
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(2022-06-06)Department: ChemistryViral life cycles are facilitated by protein-protein interactions between viral proteins and the host counterparts to ensure each stage of the replication is productive. These interactions mark potential therapeutic ...
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(2018-03-27)Department: ChemistrySeparation of complex biological samples is major challenge in bioanalytical chemistry. Ion mobility spectrometry (IM) is an emerging analytical method which provides an additional method to separate structurally similar ...
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(2005-12-06)Department: ChemistryThe stereo structures of variety chiral molecules were studied by vibrational circular dichroism (VCD), optical rotation (OR), and density functional theory in this dissertation. The error ranges in the density functional ...
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(2024-04-04)Department: ChemistryTransition metal allyl complexes are a class of compounds that are both historically important and currently relevant. The parent allyl ligand (C3H5-) can be modified with sterically bulky R groups (R = trimethylsilyl. ...
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(2015-11-19)Department: ChemistryMechanochemical methods of synthesis (specifically grinding and milling) have not yet been widely used by organometallic chemists. This thesis surveys recent developments in the field, outlining differences that can occur ...
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(2022-08-17)Department: ChemistryThe endoplasmic reticulum (ER), responsible for processing approximately one-third of the human proteome including most secreted and membrane proteins, plays a pivotal role in protein homeostasis (proteostasis). Dysregulation ...
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(2016-07-14)Department: ChemistryMalaria is an entirely preventable and treatable disease, yet it is endemic in nearly half of the countries around the world. One of the most important drug targets for this disease is the hemozoin formation pathway, a ...
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(2017-02-15)Department: ChemistryThis work describes three separate projects, for which Density Functional Theory (DFT) computations provide a unifying theme. The DFT approach gives a theoretically sound way to model the chemical and physical properties ...
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(2015-12-16)Department: ChemistryOrthosomycins are highly decorated oligosaccharides with potent activity against a variety of Gram-positive bacteria including methicillin-resistant staphylococci and vancomycin-resistant enterococci. The research in this ...
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(2018-03-26)Department: ChemistryPolyunsaturated fatty acids can be liberated from phospholipids in the membrane bilayer and enzymatically converted to oxygenated bioactive lipid compounds that contribute to the pathology, or in some cases, the resolution ...