Browsing Electronic Theses and Dissertations by Department "Cell and Developmental Biology"
Now showing items 161-179 of 179
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(2007-04-03)Department: Cell and Developmental BiologyThe small GTPase Rab11 family proteins have been implicated in the plasma membrane recycling system in such diverse model systems as H/K-ATPase trafficking in parietal cells to GLUT4 trafficking in heart and skeletal muscle. ...
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(2015-06-05)Department: Cell and Developmental BiologyRetinoic acid (RA) has been used therapeutically to reduce injury and fibrosis in models of acute kidney injury (AKI), but little is known about whether and how this pathway is normally regulated, and what role it plays ...
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(2016-06-02)Department: Cell and Developmental BiologyCELL AND DEVELOPMENTAL BIOLOGY The role of the BMP antagonist Gremlin2 during cardiac tissue repair Lehanna Nalani Sanders Dissertation under the direction of Professor Antonis Hatzopoulos Acute myocardial infarction ...
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The Role of the Transactivation Domain in c-Myc Mediated Cell Cycle Progression and Transformation (2008-04-14)Department: Cell and Developmental BiologyDissertation under the direction of Professor Stephen R. Hann c-Myc is a transcription factor whose deregulation has been implicated in numerous cancers. The biological responses resulting from Myc deregulation include ...
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(2016-08-31)Department: Cell and Developmental BiologyThe ubiquitin–proteasome system (UPS) influences gene transcription in multiple ways. One way in which the UPS impacts transcription centers on transcriptional activators, the function of which can be stimulated by components ...
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(2014-04-30)Department: Cell and Developmental BiologySonic hedgehog (Shh) signaling regulates critical processes during embryonic development and in homeostasis of adult tissues. Deregulated pathway activity is a major factor underlying the etiology of numerous developmental ...
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(2011-07-29)Department: Cell and Developmental BiologyEpithelial cells establish apical and basolateral (BL) membranes with distinct protein and lipid compositions. To achieve this spatial asymmetry, the cell utilizes a variety of mechanisms for differential sorting, delivery ...
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(2010-07-12)Department: Cell and Developmental BiologyAlthough it is known that the response of endothelial cells to atherogenic disturbed flow is distinct from that elicited by non-atherogenic laminar flow, the mechanisms involved are poorly understood. Observing that ...
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(2011-08-02)Department: Cell and Developmental BiologyDisruption of intestinal epithelial homeostasis, including enhanced apoptosis, is a hallmark of inflammatory bowel disease (IBD). We have shown that tumor necrosis factor (TNF) increases the kinase activity of ErbB4, a ...
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(2011-04-08)Department: Cell and Developmental Biologyc-Myc is frequently deregulated in human cancers. While deregulated c-Myc leads to tumor growth, it also triggers apoptosis in partnership with tumor suppressors such as ARF and p53. Apoptosis induced by c-Myc is a ...
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(2006-04-14)Department: Cell and Developmental BiologyWhile localized tumor growth may cause organ dysfunction and even death, metastases cause the vast majority (~90%) of human cancer deaths. Both autocrine and paracrine transforming growth factor-beta (TGF-beta) have been ...
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(2015-07-17)Department: Cell and Developmental BiologyProteins that regulate cell polarity are fundamental for metazoan biology and are necessary for proper development of tissues and organs. In light of polarity genes’ fundamental role in tissue organization, disruptions ...
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(2010-03-18)Department: Cell and Developmental BiologyCoordinated movement depends on specific connections between neurons, yet mechanisms that govern synaptic specificity are poorly understood. The simple, well-defined motor circuit of the nematode, C. elegans provides an ...
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(2013-05-09)Department: Cell and Developmental BiologyEpithelial cells called enterocytes line the lumen of the small intestine and are responsible for nutrient processing and barrier maintenance. Enterocytes have highly ordered actin arrays, or brush borders, on their apical ...
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(2016-09-12)Department: Cell and Developmental BiologyEukaryotic cells respond to stress by reprogramming their gene expression program to inhibit global protein synthesis and direct translationally silenced mRNAs to cytoplasmic foci known as stress granules (SGs). SGs function ...
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(2014-07-31)Department: Cell and Developmental BiologyColorectal carcinoma is the third leading cause of cancer related mortality within the United States. Over 90% of these deaths can be attributed to distant metastasis. Therefore, understanding the signaling perturbations ...
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(2019-01-15)Department: Cell and Developmental BiologyEndoplasmic reticulum (ER) stress in type II AECs has been associated with pathogenesis of IPF; however, factors inducing ER stress and downstream mechanisms through which ER stress impacts phenotype of type II AECs are ...
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(2015-05-27)Department: Cell and Developmental BiologyThe spliceosome is a dynamic macromolecular machine composed of five different small nuclear ribonucleoproteins (snRNPs), the Nineteen Complex (NTC), RNA helicases, and other proteins that catalyze the removal of introns ...
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(2017-02-24)Department: Cell and Developmental BiologyReprogramming of pancreatic cells into new beta-like cells is a potential therapy for Type 1 diabetes. Pancreatic acinar cells are an appealing target for cellular reprogramming since they are abundant, derived from a ...