Browsing Electronic Theses and Dissertations by Department "Chemistry"
Now showing items 141-160 of 363
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(2009-07-19)Department: ChemistryBiomineralization is the formation of organic-inorganic composites by organisms. Originally evolved as a protective mechanism, this complex process has also become a recognized contributor to several disease states, ranging ...
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(2013-02-26)Department: ChemistryThe emergence of drug resistant strains of Plasmodium spp. creates a critical need for the development of novel antimalarials. Hemozoin, a crystalline heme detoxification biomineral vital to parasite survival, serves as ...
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(2012-04-19)Department: ChemistryMental health problems related to dysfunction of serotonin transporter protein and norepinephrine transporter protein are an ever increasing burden on the population and the health care system. The Rosenthal lab uses a ...
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(2009-06-05)Department: ChemistryThis project focused upon advancing nanotechnology for applications in biological assays using highly fluorescent nanocrystals, quantum dots, with high affinity peptide neurotoxins as targeting molecules. Specifically, ...
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(2016-06-08)Department: ChemistryMatrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) allows for the study of protein distributions in biological tissue specimens. This has traditionally been performed using time-of-flight ...
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(2009-08-04)Department: ChemistryBiological systems are extremely complex and new tools are necessary to effectively enhance our knowledge and understanding of their underlying mechanisms. Mass spectrometry has proven to be an essential technology for ...
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(2006-11-01)Department: ChemistryAlloy nanocrystals provide an additional degree of freedom in selecting desirable properties for nanoscale engineering because their physical and optical properties depend on both size and composition. This dissertation ...
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(2018-05-16)Department: ChemistryStreptococcus agalactiae (Group B strep, GBS) is a common infant pathogen that causes sepsis and meningitis. Human milk provides nutrition for the developing infant, and breast milk consumption leads to critical modulation ...
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(2019-03-22)Department: ChemistryThe increasing prevalence of antibiotic resistance coupled with a dramatically slowed rate of novel antibiotic discovery has created an environment wherein antimicrobial resistance is one of the most serious threats to ...
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(2022-03-21)Department: ChemistryStreptococcus agalactiae (Group B Streptococcus, GBS) is an opportunistic bacterium that is commonly isolated from the female gastrointestinal and reproductive tracts. GBS colonization of the rectovaginal mucosa during ...
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(2018-07-31)Department: ChemistryVanadium dioxide (VO2) is a unique transition metal oxide that undergoes a first-order phase transition at 68°C from a semiconducting monoclinic phase (M) to a metallic rutile phase (R). This has made VO2 of great interest ...
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Identification and Scoring of Partial Covalent Interactions in Proteins and Protein Ligand Complexes (2013-12-16)Department: ChemistryPartial covalent interactions (PCI) such as hydrogen bonds, salt bridges, cation-π, and π-π interactions contribute to protein thermostability. Algorithms that identify PCIs rely on pairwise atom-atom angles and distances, ...
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(2017-03-03)Department: ChemistryDisease is characterized by signature molecular changes in affected tissues and organs. Diseases cause disruption and dysregulation of a number of biological molecules, including proteins, lipids, metal, and small molecules. ...
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(2014-07-07)Department: ChemistryDiabetic nephropathy (DN) leads to progressive decline in renal function and is the leading cause of end-stage renal disease. Much still remains unknown about the pathogenesis of this disease. This project investigates the ...
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(2020-08-14)Department: ChemistryInfection and disease are rooted in chemical changes at or below the cellular level. Many of the causative chemical changes that result in potentially deadly conditions localize to specific structures or cells within tissues ...
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Improved synthesis of tetraethylene glycol-derived thiol for monolayer-protected gold nanoparticles (2010-11-23)Department: ChemistryImproved synthesis of ω-functionalized mercapto-tetraethylene glycols and single-phase synthesis of gold nanoparticles are described. Tetraethylene glycol is converted to mercaptotetraethylene glycol through thioacetate-protected ...
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(2015-04-15)Department: ChemistryProteins play a pivotal role in the functions of a cell. Structural information about proteins facilitates the understanding of their function. Limitations of experimental methods make it difficult to determine the structure ...
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(2022-09-27)Department: ChemistrySite-directed spin labeling of proteins via non-canonical amino acids (ncAAs) is a non-traditional method for the measurement of pseudocontact shifts (PCSs) by nuclear magnetic resonance (NMR) spectroscopy. PCSs provide ...
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(2018-03-26)Department: ChemistryMembrane proteins are an important class of proteins that represent approximately 30% of the open reading frame. However, due to their inherent flexibility, membrane proteins are difficult to structurally characterize, ...
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(2021-05-10)Department: ChemistryLateral flow assays (LFAs) are paper-based, point-of-care (POC) diagnostic tests that have become ubiquitous in healthcare systems because they are inexpensive, rapid, robust, and easy to use. LFAs have been indispensable ...