Browsing Electronic Theses and Dissertations by Department "Pharmacology"
Now showing items 121-140 of 143
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(2014-04-25)Department: PharmacologyMutations in SCN5A encoding the cardiac voltage-gated sodium channel (NaV1.5) can result in severe life-threatening cardiac arrhythmias such as long QT syndrome (LQTS). However, the molecular basis for arrhythmia susceptibility ...
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(2023-03-22)Department: PharmacologyValue-based decision-making is at the core of nearly all motivated behaviors and requires the ability to associate outcomes with specific actions and make adaptive decisions about future behavioral action. At the core of ...
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(2015-11-27)Department: PharmacologyAlpha4 is multi-domain protein with a structured N-terminal region that binds to PP2A family catalytic subunits and an unstructured C-terminal domain that binds to E3-ubiquitin ligases. Unlike typical regulatory subunits ...
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The role of Ca2+/calmodulin-dependent kinase II in normal and abnormal early postnatal development (2010-06-29)Department: PharmacologyTHE ROLE OF CA2+/CALMODULIN-DEPENDENT KINASE II IN NORMAL AND ABNORMAL EARLY POSTNATAL DEVELOPMENT RICHARD GUSTIN Dissertation under the direction of Professor Roger J. Colbran Ca2+/calmodulin-dependent kinase II (CaMKII) ...
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(2010-08-04)Department: PharmacologyDopaminergic neurotransmission is a critical component in the regulation of several behaviors, including cognition, motor function, motivation, and reward. Abnormalities in dopamine (DA) signaling have been linked to ...
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(2015-08-11)Department: PharmacologyOf the eight metabotropic glutamate (mGlu) receptor subtypes, only metabotropic glutamate receptor 7 (mGlu7) is expressed presynaptically at the Schaffer Collateral (SC)-CA1 synapse in the hippocampus in adult animals. ...
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(2012-11-20)Department: PharmacologyMetastases are the primary cause of death in breast cancer patients, most often appearing in the bones. Following treatment of the primary cancer, emotional and psychosocial factors within this population hasten time to ...
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(2015-07-23)Department: PharmacologyBasement membranes are a distinct form of extracellular matrix responsible for signal transduction and mechanical integrity throughout development, in mature tissues, and during wound healing. The collagen IV scaffold of ...
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(2015-08-28)Department: PharmacologyDiabetic retinopathy (DR) is disease of microvascular complications and is a leading cause of blindness in working age adults. DR consists of two main stages: the early non-proliferative stage is driven primarily by ...
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The Role of the Prostaglandin E2 EP3 Receptor in Obesity, Insulin Resistance, and Glycemic Control (2015-12-01)Department: PharmacologyMice carrying a targeted disruption of the prostaglandin E2 E-prostanoid receptor 3 (EP3) gene, Ptger3, were fed a high-fat diet (HFD), or a micronutrient matched control diet, to investigate the effects of disrupted ...
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(2011-12-15)Department: PharmacologyCoronary artery disease accounts for 54% of all cardiovascular disease in the United States. To provide novel therapeutic targets for the prevention and treatment of coronary artery disease, my dissertation project focused ...
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(2014-11-04)Department: PharmacologyAortic stiffening is an important cause of systolic hypertension and predispose to cardiovascular morbidity and mortality. The precise mechanisms underlying aortic stiffening remain undefined. Using multiple genetically ...
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(2015-11-24)Department: PharmacologyArrestin selectively binds the phosphorylated active receptor to either terminate the G protein dependent signaling or initiate G protein independent signaling. Receptor binding induces global conformational changes in ...
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(2014-10-15)Department: PharmacologyAstrocytes are one type of glia in the central nervous system, and they provide metabolic and structural support to neurons. Following injury astrocytes undergo an injury stress response known as reactive gliosis. Gliosis ...
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(2010-02-16)Department: PharmacologyCell motility plays important roles in development, wound healing, and metastasis. Cells move either spontaneously, in a non-directed fashion, or in response to chemotactic signals, in a directed fashion. Even though they ...
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(2022-08-17)Department: PharmacologyDifferential expression of both Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and its soluble fragment have been linked to Alzheimer’s disease (AD) risk in animal models and humans. The TREM2 pathway represents ...
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(2007-04-20)Department: PharmacologyExtensive evidence suggests that 5-HT2 receptors may play a role in mental disorders including schizophrenia, depression and psychosis. In addition, several studies indicate that Gq-coupled 5-HT2A family of receptors are ...
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(2022-03-25)Department: PharmacologyAlzheimer's disease (AD) is a neurodegenerative disorder that is characterized by neurodegeneration, memory loss and cognitive impairment. Sporadic late-onset AD is the most common form of the disease; it makes up approximately ...
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(2011-04-14)Department: PharmacologyThis project is concerned with mechanisms underlying osteoblast differentiation, a critical process during bone remodeling and repair. In this dissertation I explored novel regulators for osteoblast differentiation by ...
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(2018-08-03)Department: PharmacologyAmyloid precursor protein (APP) is a type I transmembrane protein and has been studied extensively due to its relevance to Alzheimer’s disease. However, its subcellular distribution and the mechanisms that regulate its ...