Browsing Electronic Theses and Dissertations by Department "Cancer Biology"
Now showing items 121-140 of 161
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(2015-03-24)Department: Cancer BiologyLung cancer remains the leading cause of cancer related deaths in the United States despite a significant number of advancements in the molecular diagnosis and treatment of this disease. Recent genome wide expression ...
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(2022-07-15)Department: Cancer BiologyVascular endothelial cells (ECs) are specialized components in the tumor microenvironment (TME) that line the inner walls of blood vessels and serve as precursors for new blood vessel formation (angiogenesis). Compared to ...
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(2008-09-23)Department: Cancer BiologyThe transforming growth factor beta (TGF-â) pathway significantly regulates mammary development and tumorigenesis. In human cancer, its signaling pathways are often modified or lost during tumor progression. Prior to ...
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(2006-07-07)Department: Cancer BiologyContribution of stromal TGF-b to prostate cancer progression Human prostate carcinoma-associated fibroblasts (CAF) induce malignant transformation in an initiated but non-malignant human prostatic epithelial cell line ...
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(2014-12-02)Department: Cancer BiologyBreast cancer is the leading cancer diagnosis in pre-menopausal women in the U.S. Of these breast cancers, 25% are diagnosed 2-5 years post-partum. Unfortunately, post-partum breast cancers (ppBCs) are highly metastatic. ...
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(2021-05-12)Department: Cancer BiologyTGFβ signaling via SMAD4 is frequently altered in sporadic colorectal cancer (CRC), inflammatory bowel disease (IBD), and colitis-associated cancer (CAC). Little is known about how TGFβ/SMAD4 modulate inflammation or barrier ...
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(2013-07-17)Department: Cancer BiologyCell adhesion molecules play a vital role in modulating both normal and tumor cell behavior. The focus of my research has been to investigate the contribution of Activated Leukocyte Cell Adhesion Molecule (ALCAM) to tumor ...
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(2020-05-19)Department: Cancer BiologyDespite significant advancements in cancer research, prevention, and therapeutics, cancer remains a major public health problem. The EphA2 receptor tyrosine kinase and ephrin-A1 ligand signaling axis has long been implicated ...
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(2016-03-30)Department: Cancer BiologyDysregulation of receptor tyrosine kinases (RTKs) contributes to cellular transformation and cancer progression by disrupting key metabolic signaling pathways. The EPHA2 RTK is overexpressed in aggressive forms of breast ...
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(2016-03-17)Department: Cancer BiologyEpithelial cancers of the lung, colon, breast, and pancreas comprise the top four most deadly cancers. Progress has been made in treating primary epithelial tumors, however metastatic tumors remain largely incurable and ...
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(2010-09-01)Department: Cancer BiologyThe major goal of this thesis is to investigate the role of MT1-MMP in kidney development. Our results demonstrate that loss of MT1-MMP leads to a renal phenotype characterized by a moderate decrease in ureteric bud branching ...
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(2022-11-17)Department: Cancer BiologyThe emergence of immunotherapy as a new pillar of cancer treatment is due to the success of immune checkpoint blockade drugs. However, many patients receiving checkpoint blockade fail to respond, and consensus evidence ...
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(2013-05-23)Department: Cancer BiologyAdult T-cell leukemia/lymphoma (ATLL) is an incurable peripheral T-cell malignancy where most patients succumb within the first year of diagnosis. Development of ATLL requires human T-cell lymphotrophic virus type 1 ...
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(2007-04-14)Department: Cancer BiologyAlthough the signaling mechanisms of the apoptotic pathway have been extensively studied, there is still much left unknown. A key regulator protein, 14-3-3, is known to bind and protect BAD phosphorylation sites serine ...
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The role of blood vessel epicardial substance in the maintenance of intestinal epithelial integrity (2016-02-02)Department: Cancer BiologyBlood Vessel Epicardial Substance (BVES/Popdc1) is a junctional-associated transmembrane protein that is underexpressed in a number of malignancies and regulates epithelial-to-mesenchymal transition. BVES is known to ...
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(2010-08-25)Department: Cancer BiologyC/EBPbeta is essential for mammary gland growth and development and has been associated with poor prognosis in breast cancer. Overexpression of C/EBPbeta2 in MCF10A cells, a model of normal mammary epithelial cells, results ...
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(2014-04-08)Department: Cancer BiologyPerturbation of physiological processes stimulate a cascade of events resulting in adverse pathogical conditions, the most predominant being cancer. Colorectal cancer (CRC) is the third most common cancer in the United ...
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(2015-03-19)Department: Cancer BiologyThe branched actin regulator cortactin is a central element connecting signaling pathways with the actin cytoskeleton and plays a role in diverse cellular processes. Cortactin-mediated actin assembly is known to contribute ...
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(2008-08-25)Department: Cancer BiologyThe EphA2 receptor belongs to the recently cloned Eph family of receptor tyrosine kinase (RTK). High levels of EphA2 RTK have been detected in 60-90% of human breast cancer specimens, both in breast cancer cells and in ...
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(2016-11-03)Department: Cancer BiologyHead and neck squamous cell carcinoma is a frequent and serious malignancy that accounts for more than 300,000 deaths world wide each year, the majority of which are the result of local invasion and lymph node metastasis. ...