Browsing Electronic Theses and Dissertations by Department "Chemistry"
Now showing items 101-120 of 363
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(2007-12-27)Department: ChemistryIn recent years, technological advances have improved our understanding of disease and infection at the molecular level. Genomic and proteomic studies have identified a large number of potential therapeutic targets for ...
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(2011-04-06)Department: ChemistryNucleoside analogs comprise a large therapeutic class applied to the treatment of HIV, hepatitis, and other diseases. Their broad use and applicability are in contrast to their high manufacturing cost. Given the similarity ...
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(2010-05-13)Department: ChemistryNucleotide analogues are essential pharmaceuticals with challenges in preparation due to need for control over regio and stereochemistry, and protecting group manipulations. Enzymatic biosynthesis of these analogues provides ...
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(2019-03-14)Department: ChemistryG-protein coupled receptors (GPCRs) are ubiquitous in drug development programs; one third of FDA approved therapeutics target GPCRs. Despite this, many GPCRs remain in obscurity as their exact physiological role in ...
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(2022-01-14)Department: ChemistryThe human neuropeptide Y (NPY) receptor family (Y1R, Y2R, Y4R, and Y5R) are comprised of G-protein coupled receptors (GPCR) that bind the ligands neuropeptide Y (NPY), polypeptide YY (PYY), and pancreatic polypeptide (PP). ...
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(2019-12-12)Department: ChemistryThe metabotropic glutamate (mGlu) receptors belong to the Class C family of G protein-coupled receptors (GPCRs) and are involved with the modulation of neuronal excitability and synaptic transmission within the central ...
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(2021-07-22)Department: ChemistryHerein, we first describe the discovery of the first inhibitor of the inward rectifying potassium channel 4.1/5.1 (Kir4.1/5.1) heterotetramer, VU6036720. The potency and selectivity of VU’720 was established using fluorescence‐ ...
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(2022-08-11)Department: ChemistryClostridioides difficile is a nosocomial gastrointestinal pathogen with a major impact on the healthcare community and limited treatment methods. This pathogen undergoes germination from a dormant spore into a vegetative ...
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(2017-08-29)Department: ChemistryProgress toward the first total synthesis of Melearoride A, a macrolide natural product from the marine fungus Penicillium meleagrinum var. viridiflavum. This compound has shown interesting synergistic antifungal activity ...
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(2014-07-22)Department: ChemistrySince the advent of molecular beacon technology, much attention has been directed toward understanding RNA expression at a single-cell level. Our laboratory has designed an approach that harnesses the advantages of both ...
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(2015-03-25)Department: ChemistryThe surface chemistry of nanocrystals of different semiconductor materials is characterized by nuclear magnetic resonance spectroscopy and the charge carrier dynamics of graded alloy quantum dots are investigated. The ...
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(2024-03-22)Department: ChemistrySince the discovery and induction of antibiotics in the 1940s, human lifespan and survival has seen drastic increases. Today, the critical tools largely responsible for those improvements are rapidly becoming obsolete due ...
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(2013-07-29)Department: ChemistryThe furanocembranoids are a family of natural products generated from oxidation and polycyclization of well-established terpene frameworks. The biosynthesis of these metabolites involves oxidative installation of butenolide ...
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(2023-06-02)Department: ChemistryEverninomicin D is a potent orthosomycin antibiotic that has a unique binding site on the 50S ribosome allowing it to inhibit protein synthesis without any cross-resistance due to other ribosome-targeting antibiotics. The ...
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(2013-02-07)Department: ChemistryThe increase in demand for energy has made Photosystem I (PSI), which can convert solar energy into a charge separation with an incredible efficiency, a topic of great research interest. By analyzing the PSI energy conversion ...
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(2016-04-11)Department: ChemistryNew technologies for model biological systems aid in drug development and toxicology by providing an in vitro environment that closely mimics in vivo conditions but require new instrumentation to meet needs in monitoring ...
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(2009-04-10)Department: ChemistryThe past decade has witnessed the birth of the field of Metabolomics, which aims to study the "chemical fingerprints" left behind by specific cellular processes. The chemical fingerprints themselves consist of the totality ...
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(2022-03-25)Department: ChemistryElectrochemical mediators, redox-active compounds used as electron transfer shuttles, are required for various electrochemical applications such as fuel or photovoltaic cells and biosensors. Biosensors, in particular, ...
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(2011-08-04)Department: ChemistryBisAMidine chiral proton catalysts are a class of mixed Brønsted acid/Brønsted base reagents amenable to both electronic and steric modification. A counterintuitive approach in which the creation of more Brønsted basic ...
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(2009-07-29)Department: ChemistryThe determination of electrophoretic properties and the size separation of monolayer protected clusters (MPCs) are presented in this thesis. MPCs are metallic nanoparticles encapsulated in a protecting thiolate monolayer. ...