Browsing Electronic Theses and Dissertations by Department "Cell and Developmental Biology"
Now showing items 101-120 of 179
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(2008-01-16)Department: Cell and Developmental BiologyA conserved biological feature of sexual reproduction in animals is that oocytes arrest in meiotic prophase and resume meiosis in response to extra-ovarian signals. While meiotic maturation signals activate highly conserved ...
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(2012-05-08)Department: Cell and Developmental BiologyThe COPII machinery is the primary mediator of ER-to-Golgi transport and mutations in different COPII (Coat Protein II complex) paralogs are associated with diverse human diseases. Each tissue has vastly different requirements ...
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(2004-04-08)Department: Cell and Developmental BiologyPeroxisome prolferator-activated receptor g (PPARg) is a member of the nuclear hormone receptor superfamily and is ligand activated by polyunsaturated fatty acids, certain arachadonic acid metabolites, and class of synthetic ...
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(2019-05-16)Department: Cell and Developmental BiologyThe epigenetic regulator WDR5 is a promising therapeutic target in leukemias expressing oncogenic translocations of the MLL1 histone methyltransferase gene. Despite the validation of the WIN site of WDR5 as a pharmacological ...
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(2012-08-22)Department: Cell and Developmental BiologyCdk1 kinase dephosphorylation and activation by Cdc25 phosphatase is essential for mitotic entry. Activated Cdk1 phosphorylates Cdc25 and other substrates, further activating Cdc25 to form a positive feedback loop that ...
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(2006-04-14)Department: Cell and Developmental BiologyDynamic spatiotemporal expression of the nodal gene and its orthologs is involved in the dose-dependent induction and patterning of mesendoderm during early vertebrate embryogenesis. In loss of function studies, a strong ...
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(2011-09-02)Department: Cell and Developmental BiologyFirst identified as a pro-apoptotic member in the programmed cell death pathway, BH3 interacting domain death agonist (BID) has recently been demonstrated to play a role to maintain genomic integrity and execute DNA damage ...
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(2016-11-18)Department: Cell and Developmental BiologyProgrammed cell death (PCD) is an important process necessary for the maintenance of tissues in adult organisms and the crafting of distinct tissues in development. The two main types of PCD, apoptosis and necroptosis (i.e. ...
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(2018-06-18)Department: Cell and Developmental BiologySingle cell tools have great potential to characterize mechanisms of oncogenesis and treatment resistance. To date, single cell quantitative cytometry has been widely applied in the setting of blood cancer. However, few ...
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Raf-1 kinase regulates intestinal epithelial cell survival in response to pro-inflammatory stimuli (2008-04-08)Department: Cell and Developmental BiologyThe maintenance of the intestinal epithelium is dependent upon controlled regulation of cell proliferation and apoptosis, or programmed cell death. Dysregulation of either of these processes can compromise the integrity ...
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(2008-07-26)Department: Cell and Developmental BiologyWnt/beta-catenin signaling controls various cell fates in metazoan development and is misregulated in several cancers and developmental disorders. Binding of a Wnt ligand to its transmembrane coreceptors, Frizzled (Fz) ...
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(2019-05-15)Department: Cell and Developmental BiologyThe mitotic spindle is the microtubule (MT)-based machine that segregates a replicated set of chromosomes during cell division. Many chemotherapeutics target the mitotic spindle by altering or disrupting microtubules, the ...
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(2014-08-18)Department: Cell and Developmental BiologyIn a biochemical screen Anaphase-Promoting Complex (APC) substrates, we identified Drosophila MCPH1 isoform B (dMCPH1-B) as a substrate of APCCdh1. dMCPH1-B undergoes Cdh1-dependent degradation in Xenopus egg extract, which ...
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(2012-03-31)Department: Cell and Developmental BiologyCanonical Wnt signaling regulates many fundamental developmental processes and is misregulated in a variety of disease states in humans. Ubiquitylation has been shown to play critical roles in the regulation of Wnt signal ...
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(2019-02-28)Department: Cell and Developmental BiologyCollagens are the structural components of extracellular matrix (ECM), constituting over 30% of dry body weight in vertebrates. Despite their abundance, mechanisms regulating collagen secretion during tissue homeostasis ...
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(2011-07-25)Department: Cell and Developmental BiologyIn a screen for cell-cycle regulators, we identified a Drosophila maternal effect-lethal mutant that we named “no poles” (nopo). Embryos from nopo females undergo mitotic arrest with barrel-shaped, acentrosomal spindles ...
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(2013-12-10)Department: Cell and Developmental BiologyCytoplasmic dynein is a large, multimeric complex that walks along microtubules to perform multiple functions within the cell. This motor is commonly found associated with the dynein-activating complex, dynactin. Dynein ...
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(2013-11-08)Department: Cell and Developmental BiologyDynein, a microtubule motor protein complex, plays critical roles in cell-cycle progression in many systems. The dynein accessory factor <i>LIS1</i>, first identified as a causative factor of the human brain disorder ...
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(2009-09-22)Department: Cell and Developmental BiologyDynein is a minus-end directed microtubule motor complex that is required for a diverse range of biological processes, from intracellular-cargo transport to cell migration. Dynein is regulated at multiple levels and its ...
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(2005-04-20)Department: Cell and Developmental BiologyProgression through the eukaryotic cell cycle involves the coordinated activation and inactivation of cyclin dependent kinases. One such family member, Cdk1p in a complex with Cyclin B, is activated at the G2/M transition ...