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Now showing items 21-27 of 27
Muscle Insulin Resistance: Novel Mechanisms and New Treatment Targets
(2013-05-28)
This project investigated the significance of extramyocellular barriers to the pathogenesis of skeletal muscle insulin resistance and their potential as therapeutic targets. The goals of this dissertation were to determine ...
The role of insulin and Akt in the regulation of the norepinephrine transporter and monoamine homeostasis
(2010-07-15)
Monoamine signaling in the central nervous system plays an essential role in circuits involving attention, mood, memory, and stress as well as providing pivotal support for autonomic function in the peripheral nervous ...
Macrophages and Endothelial Cells in the Pancreatic Islet Microenvironment Promote β Cell Regeneration
(2015-07-16)
Reduced pancreatic β cell mass is a hallmark of diabetes, which makes the ability to increase or restore β cell mass a major therapeutic goal. While testing the hypothesis that increased endothelial cell signaling would ...
The Role of Physical Activity and Obesity in the Occurrence of Major Cardiovascular Events and Mortality among a Low-Income Population with Diabetes
(2014-07-22)
EPIDEMIOLOGY
The Role of Physical Activity and Obesity in the Occurrence of Major Cardiovascular Events and Mortality among a Low-Income Population with Diabetes
Kimberly R. Glenn
Dissertation under the direction of Professor ...
Development of Drug Delivery Vehicles for Biomedical Applications
(2017-07-20)
Polymeric nanoparticles have historically been shown to be valuable tools for the solubilization and delivery of small molecule hydrophobic drugs. However, most systems do not address obstacles associated with off-target ...
Implicit feedback: a new way of measuring patients interests in web-based health literature
(2013-04-18)
Existing research on evaluating patients’ interests has focused on user surveys, which encounter problems such as high financial and time costs as well as a low user participation rate. To address these problems, this study ...
Investigations into islet pdx1 activity: contribution to mature β-cell identity and the identification and characterization of Pdx1 coregulators
(2015-05-28)
Pdx1 is a transcription factor of fundamental importance to pancreas formation and adult islet β-cell function. However, little is known regarding its role in mature β-cells or the positive- and negative-acting coregulators ...