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Role of Invariant Natural Killer T Cells in Tularemia-like Disease in Mice
(2015-11-13)
The respiratory mucosa is a major site for pathogen invasion and, hence, a site requiring constant immune surveillance. The type I, semi-invariant natural killer T (iNKT) cells are enriched within the lung vasculature. ...
NF-kappa B signaling and inflammasome activation in developing fetal lung macrophages
(2014-12-31)
Bronchopulmonary dysplasia is a life-threatening lung disease affecting low birth weight preterm infants. While the occurrence of BPD is correlated with chorioamnionitis, the origination and pathway of fetal lung inflammation ...
The Role of the Prostaglandin E2 EP3 Receptor in Obesity, Insulin Resistance, and Glycemic Control
(2015-12-01)
Mice carrying a targeted disruption of the prostaglandin E2 E-prostanoid receptor 3 (EP3) gene, Ptger3, were fed a high-fat diet (HFD), or a micronutrient matched control diet, to investigate the effects of disrupted ...
The role of Y1R-expressing dorsal horn interneurons in pain
(2011-12-20)
The spinal Neuropeptide Y (NPY) system is a potential target for development of new pain therapeutics. NPY and two of its receptors (Y1 and Y2) are found in the superficial dorsal horn of the spinal cord, a key area of ...
The multifaceted role of eosinophils in adipose tissue: from metabolism to allergy
(2017-12-12)
Obesity has reached epidemic proportions worldwide, with some of the greatest severity in the United States. The most recent data reports ~70% of the American population is overweight (BMI ≥ 25 kg/m2) and ~35% obese (BMI ...
TGFbeta signaling enhances wound healing inflammation in post-partum breast cancer.
(2014-12-02)
Breast cancer is the leading cancer diagnosis in pre-menopausal women in the U.S. Of these breast cancers, 25% are diagnosed 2-5 years post-partum. Unfortunately, post-partum breast cancers (ppBCs) are highly metastatic. ...
The Role of Factor XI During Murine Polymicrobial Sepsis
(2016-11-21)
Sepsis is a systemic inflammatory response to infection. It is often accompanied by the pathologic production of thrombin, the key enzyme in blood plasma responsible for coagulation, and by contact activation, which is a ...
Investigation of epithelial canonical and non-canonical NF-κB signaling in lung adenocarcinoma
(2016-02-19)
Nuclear factor κ-light chain enhancer of activated B cells (NF-κB) is a transcription factor that can be activated through canonical or non-canonical signaling pathways, and activation of both pathways has been observed ...
Variables that influence transcription factor-mediated acinar to beta cell reprogramming
(2017-02-24)
Reprogramming of pancreatic cells into new beta-like cells is a potential therapy for Type 1 diabetes. Pancreatic acinar cells are an appealing target for cellular reprogramming since they are abundant, derived from a ...
The role of PPARβ/δ in diabetic retinopathy
(2015-08-28)
Diabetic retinopathy (DR) is disease of microvascular complications and is a leading cause of blindness in working age adults. DR consists of two main stages: the early non-proliferative stage is driven primarily by ...