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Now showing items 21-27 of 27
Inflammatory cytokines, cachexia and symptoms in patients with head and neck cancer
(2015-07-15)
The precise cause of cancer cachexia is unknown. It is a syndrome associated with weight loss, lipolysis, muscle wasting, anorexia, chronic nausea and asthenia. Patients with head and neck cancer (HNC) are particularly ...
w-Alkynyl Fatty Acids: Surrogates to Study Protein Adduction by Endogenously Generated Lipid Electrophiles
(2015-07-21)
Polyunsaturated Fatty Acids (PUFAs) are oxidized both enzymatically and by autoxidation to many inflammatory signaling molecules, which have been detected in multiple disease states. Oxidized PUFAs can further react to ...
The role of polyunsaturated fatty acid and eicosanoid biosynthesis in the pathogenesis of cystic fibrosis
(2014-06-24)
The primary cause of morbidity and mortality in cystic fibrosis is progressive pulmonary disease, an important component of which is a hyperactive inflammatory response, the mechanisms of which are not completely understood. ...
Elucidating the Role of Iron-Handling Macrophages in Adipose Tissue
(2018-07-22)
The phagocytic nature and oxidative resiliency of macrophages not only allows them to function as innate immune cells but also to respond to specific tissue needs, such as iron homeostasis. MFehi ATMs are a subtype of ...
Peptide-functionalized Polymers Regulating Angiogenesis and Inflammation in Peripheral Artery Disease
(2014-04-07)
Peripheral artery disease (PAD) is characterized by platelet activation and aggregation on arterial walls, resulting in vessel occlusion and ischemia. To treat PAD, it is desirable to have a high degree of angiogenesis to ...
The Role of Retinoic Acid Signaling in Acute Kidney Injury
(2015-06-05)
Retinoic acid (RA) has been used therapeutically to reduce injury and fibrosis in models of acute kidney injury (AKI), but little is known about whether and how this pathway is normally regulated, and what role it plays ...
Parsing Inflammatory Cues in Angiogenesis using Bioactive Hydrogels
(2011-04-15)
Both angiogenesis and inflammation are inescapable in vivo responses to any type of biomaterials implanted for regeneration. Continuous progress has been made in biomaterial design to facilitate tissue interactions with ...