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An Engineering Approach to Understanding the Bone-Tumor Microenvironment: In Vitro Modeling and Drug Delivery Strategies to Improve Bone-Metastatic Patient Outcomes
(2019-03-25)
Metastasis is the major prognostic factor for cancer patient survival, and breast tumors have a striking propensity for metastasis to bone. Once tumors establish in bone, they initiate what is colloquially known as the ...
Regulation of Collagen Trafficking Pathways in Homeostasis and Disease
(2019-02-28)
Collagens are the structural components of extracellular matrix (ECM), constituting over 30% of dry body weight in vertebrates. Despite their abundance, mechanisms regulating collagen secretion during tissue homeostasis ...
Micro-Price Dynamics in Small Open Economies: Lessons from Ecuador
(2019-01-02)
From 1998 to 2003, Ecuador experienced large macroeconomic fluctuations ending with a period of stabilization under a dollarized economy. This dissertation exploits these fluctuations and a novel dataset of micro-prices ...
Streptococcus agalactiae infection of gestational tissues induces innate immune responses including the release of placental macrophage extracellular traps
(2019-01-08)
Streptococcus agalactiae, also known as Group B Streptococcus (GBS) is a common perinatal pathogen, and GBS vaginal colonization is a major risk factor for infection-related adverse pregnancy outcomes including preterm ...
Lysophospholipases as Mediators of Bioactive Lipid Metabolism and Signaling
(2019-01-02)
Lysophospholipase enzymes, lysophospholipase A1 (LYPLA1) and lysophospholipase A2 (LYPLA2), are serine hydrolases responsible for the metabolism of three separate classes of bioactive lipid substrates, including ...
Functionalized Composites for 3D-Printing and Additive Manufacturing Applications
(2019-01-15)
With the ability to shorten production times, while simultaneously minimizing material waste, additive manufacturing technologies and techniques, including 3D printing, have emerged with the potential to revolutionize the ...
Genetic and Regulatory Disruptions Impacting Dopamine Transporter Function Contribute to Neuropsychiatric Disease Phenotypes
(2019-02-13)
Dopamine (DA) signaling plays an important role in the central nervous system by regulating a variety of functions including attention, motivation, reward, movement and courtship. Alterations in DA signaling have been ...
Developing Highly Tunable Polymer-based Networks for Drug Delivery Applications
(2019-02-18)
Polymers possess many properties which make them ideal for drug delivery platforms, yet both the development and manufacturing creates challenges toward the material advancement. By governing the functionality of polymers ...
Image-guidance in ophthalmic surgery using optical coherence tomography
(2019-01-21)
Ophthalmic surgery involves manipulation of layered tissue structures on milli- to micrometer scales. Traditional surgical microscopes provide a two-dimensional view of the surgical field with limited depth perception which ...
MOLECULAR DETERMINANTS OF HUMAN ANTIBODY MEDIATED INHIBITION OF HUMAN NOROVIRUS
(2019-03-12)
Human noroviruses (HuNoVs) are the leading cause of acute nonbacterial gastroenteritis and are responsible for 19-21 million cases of infection in the U.S. each year. There are currently no licensed vaccines, therapeutics, ...