Search
Now showing items 1-3 of 3
Characterizing the role of the Est1 protein in stimulating the recruitment of the Est3 protein to the yeast telomerase complex
(2012-06-11)
Telomeres are protective protein/DNA complexes that cap the ends of linear chromosomes. The repetitive, TG-rich telomeric sequences are elongated by the telomerase ribonucleoprotein. In Saccharomyces cerevisiae, the ...
Analyzing genome integrity during DNA replication using iPOND (isolation of Proteins On Nascent DNA)
(2013-07-12)
The in vivo analysis of dynamic events that protect genomic and epigenomic integrity during DNA replication has been a challenging task. The proteins that ensure the accurate inheritance of the genome act directly at ...
A common mechanism of ATR activation by TOPBP1 and ETAA1
(2021-02-12)
Human cells are constantly exposed to endogenous and exogenous sources of DNA damage that cause thousands of DNA lesions in each cell every day. Accurate repair of these lesions ensures maintenance of genome stability and ...