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Inflammation and accumulating risk for developing psychiatric disorders
(2016-10-20)
The immune system and brain are intricately intertwined in both development and adult function. Unfortunately, this relationship can lead to dysfunction when balance in either system is disturbed. Inflammation does not ...
The role of PPARβ/δ in diabetic retinopathy
(2015-08-28)
Diabetic retinopathy (DR) is disease of microvascular complications and is a leading cause of blindness in working age adults. DR consists of two main stages: the early non-proliferative stage is driven primarily by ...
NF-κB interacts with SP3 to limit SP1-mediated FGF-10 expression in the developing fetal lung
(2013-09-18)
Arrested lung development in preterm infants leads to bronchopulmonary dysplasia (BPD). Inflammation and NF-κB activation in the fetal lung inhibit airway morphogenesis and contribute to BPD. The mesenchymal growth factor ...
Methotrexate and Rheumatoid Arthritis: At the Crossroads Between Inflammation and Defects in Cell Cycle Checkpoints
(2014-03-21)
Rheumatoid arthritis is the most common serious autoimmune disease affecting almost one percent of the human population worldwide. Methotrexate is the most commonly used disease-modifying agent in patients with rheumatoid ...
Substrate-selective Inhibition of Cyclooxygenase-2: Molecular Determinants, Probe Development, and In Vivo Effects
(2014-04-08)
Substrate-selective Inhibition of Cyclooxygenase-2:
Molecular Determinants, Probe Development, and In Vivo Effects.
Daniel John Hermanson
Dissertation under the direction of Professor Lawrence J. Marnett
Cyclooxygenase-2 ...
Investigation of epithelial canonical and non-canonical NF-κB signaling in lung adenocarcinoma
(2016-02-19)
Nuclear factor κ-light chain enhancer of activated B cells (NF-κB) is a transcription factor that can be activated through canonical or non-canonical signaling pathways, and activation of both pathways has been observed ...
Variables that influence transcription factor-mediated acinar to beta cell reprogramming
(2017-02-24)
Reprogramming of pancreatic cells into new beta-like cells is a potential therapy for Type 1 diabetes. Pancreatic acinar cells are an appealing target for cellular reprogramming since they are abundant, derived from a ...
The role of neuronal peroxisome proliferator-activated receptor delta in diet-induced obesity and hypothalamic inflammation
(2012-09-20)
Diet-induced obesity (DIO) is associated with low-grade hypothalamic inflammation, which contributes to insulin and leptin resistance leading to impaired energy balance regulation and obesity. Diets rich in monounsaturated ...
Interleukin-15-mediated immunotoxicity and exacerbation of sepsis: role of natural killer cells and interferon γ
(2016-10-05)
Immunotherapy has been a rapidly evolving field of basic and clinical research over the past decades. Interleukin (IL)-15 and its analog IL-15 superagonist (IL-15 SA, or IL-15/IL-15 receptor α) have shown promise in cancer ...
The Role of Nuclear Factor Kappa B in Myeloid Cells During Lung Carcinogenesis
(2016-11-23)
Despite recent progress, non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related mortality in the United States and new therapeutic approaches are needed. Nuclear factor κB (NF-κB) is a master regulator ...