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Now showing items 11-20 of 27
Inflammation and accumulating risk for developing psychiatric disorders
(2016-10-20)
The immune system and brain are intricately intertwined in both development and adult function. Unfortunately, this relationship can lead to dysfunction when balance in either system is disturbed. Inflammation does not ...
The role of neuronal peroxisome proliferator-activated receptor delta in diet-induced obesity and hypothalamic inflammation
(2012-09-20)
Diet-induced obesity (DIO) is associated with low-grade hypothalamic inflammation, which contributes to insulin and leptin resistance leading to impaired energy balance regulation and obesity. Diets rich in monounsaturated ...
NF-κB interacts with SP3 to limit SP1-mediated FGF-10 expression in the developing fetal lung
(2013-09-18)
Arrested lung development in preterm infants leads to bronchopulmonary dysplasia (BPD). Inflammation and NF-κB activation in the fetal lung inhibit airway morphogenesis and contribute to BPD. The mesenchymal growth factor ...
The Role of Nuclear Factor Kappa B in Myeloid Cells During Lung Carcinogenesis
(2016-11-23)
Despite recent progress, non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related mortality in the United States and new therapeutic approaches are needed. Nuclear factor κB (NF-κB) is a master regulator ...
Interleukin-15-mediated immunotoxicity and exacerbation of sepsis: role of natural killer cells and interferon γ
(2016-10-05)
Immunotherapy has been a rapidly evolving field of basic and clinical research over the past decades. Interleukin (IL)-15 and its analog IL-15 superagonist (IL-15 SA, or IL-15/IL-15 receptor α) have shown promise in cancer ...
The Roles of Oxidative Stress, Inflammation and Adaptive Immunity in Aortic Stiffening
(2014-11-04)
Aortic stiffening is an important cause of systolic hypertension and predispose to cardiovascular morbidity and mortality. The precise mechanisms underlying aortic stiffening remain undefined. Using multiple genetically ...
Inflammatory Mediators promote the development and progression of metaplasia in the stomach
(2016-03-30)
Spasmolytic polypeptide-expression metaplasia (SPEM) develops in the atrophic stomach and progresses to an intestinalized SPEM in the setting of inflammation. Different immune deficient mouse models determined that T-cells, ...
Substrate-selective Inhibition of Cyclooxygenase-2: Molecular Determinants, Probe Development, and In Vivo Effects
(2014-04-08)
Substrate-selective Inhibition of Cyclooxygenase-2:
Molecular Determinants, Probe Development, and In Vivo Effects.
Daniel John Hermanson
Dissertation under the direction of Professor Lawrence J. Marnett
Cyclooxygenase-2 ...
Effects of Leptin Receptor, C-C Chemokine Receptor 2 and Complement Factor 5 Deficiency on Mouse Immunometabolism
(2012-03-29)
Obesity is closely linked to many metabolic diseases such as insulin resistance (IR), type 2 diabetes mellitus and cardiovascular disease. In the past decade, it has been established that immune cells are recruited to ...
Methotrexate and Rheumatoid Arthritis: At the Crossroads Between Inflammation and Defects in Cell Cycle Checkpoints
(2014-03-21)
Rheumatoid arthritis is the most common serious autoimmune disease affecting almost one percent of the human population worldwide. Methotrexate is the most commonly used disease-modifying agent in patients with rheumatoid ...