Browsing School of Medicine by Title
Now showing items 42-61 of 75
-
(PLOS Pathogens, 2019-06)Precise promoter annotation is required for understanding the mechanistic basis of transcription initiation. In the context of complex genomes, such as herpesviruses where there is extensive genic overlap, identification ...
-
(DISEASE MODELS & MECHANISMS, 2019-06)In a screen for organogenesis defects in N-ethyl-N-nitrosourea (ENU)-induced mutant mice, we discovered a line carrying a mutation in Colgaft1 [collagen beta(1-O)galactosyltransferase type 1], which is required for proper ...
-
(JOURNAL OF BIOLOGICAL CHEMISTRY, 2019-06-21)Mouse studies linking adropin, a peptide hormone encoded by the energy homeostasis-associated (ENHO) gene, to biological clocks and to glucose and lipid metabolism suggest a potential therapeutic target for managing diseases ...
-
(Journal Of The American Heart Association, 2022-12-06)BackgroundPersons with HIV have a higher prevalence of coronary artery disease compared with their HIV-negative counterparts. Earlier identification of subclinical atherosclerosis may provide a greater opportunity for ...
-
(Scientific Reports, 2019-07-26)Methylmercury (MeHg) is an environmental neurotoxin with human exposure mainly from dietary intake of contaminated fish. Exposure to MeHg has been implicated in neurological damage, but research on its role in cancers, ...
-
(Nature Communications, 2019-07-22)Severe respiratory syncytial virus (RSV) infection is a major cause of morbidity and mortality in infants <2 years-old. Here we describe that high-fiber diet protects mice from RSV infection. This effect was dependent on ...
-
(Journal of Cell Biology, 2019-09)Dynamic organization of microtubule minus ends is vital for the formation and maintenance of acentrosomal microtubule arrays. In vitro, both microtubule ends switch between phases of assembly and disassembly, a behavior ...
-
(Scientific Reports, 2019-08-06)Reverse transcription polymerase chain reaction (RT-PCR) is the gold standard for the molecular diagnosis of many infectious diseases, including RNA viruses, but is generally limited to settings with access to trained ...
-
(Cellular and Molecular Gastroenterology and Hepatology, 2019)BACKGROUND & AIMS: Pancreatitis is a major cause of morbidity and mortality and is a risk factor for pancreatic tumorigenesis. Upon tissue damage, an inflammatory response, made up largely of macrophages, provides multiple ...
-
(Frontiers in Physiology, 2019-07-30)[This corrects the article DOI: 10.3389/fphys.2014.00220.]. http://hdl.handle.net/1803/10006
-
(Cell Reports, 2022-12-13)Dengue is a major public health threat. There are four dengue virus (DENV) serotypes; therefore, efforts are focused on developing safe and effective tetravalent DENV vaccines. While neutralizing antibodies contribute to ...
-
(Biomedicine & Pharmacotherapy, 2022-12-06)Stomach cancer is a leading cause of cancer death. Helicobacter pylori is a bacterial gastric pathogen that is the primary risk factor for carcinogenesis, associated with its induction of inflammation and DNA damage. ...
-
(Scand J Work Environ Health, 2022-10)Objectives Physically-demanding occupations may increase rotator cuff disease (RCD) risk and need for sur- gery. We linked a job-exposure matrix (JEM) to the UK Biobank cohort study to measure physical occupational exposures ...
-
(Plos One, 2019-06-19)p63 is a transcriptional regulator of ectodermal development that is required for basal cell proliferation and stem cell maintenance. p73 is a closely related p53 family member that is expressed in select p63-positive basal ...
-
Point mutations in the PDX1 transactivation domain impair human beta-cell development and function (Molecular Metabolism, 2019-06)Objective: Hundreds of missense mutations in the coding region of PDX1 exist; however, if these mutations predispose to diabetes mellitus is unknown. Methods: In this study, we screened a large cohort of subjects with ...
-
(Frontiers In Aging Neuroscience, 2022-12-09)Many people with coronavirus disease 2019 (COVID-19) report varying degrees of memory impairment. Neuroimaging techniques such as MRI and PET have been utilized to shed light on how COVID-19 affects brain function in humans, ...
-
(Cell Reports, 2020-03-03)Protein phosphatase 2A (PP2A) is an important regulator of signal transduction pathways and a tumor suppressor. Phosphorylation of the PP2A catalytic subunit (PP2A(C)) at tyrosine 307 has been claimed to inactivate PP2A ...
-
(Cells, 2020-01)The effect of anti-diabetic thiazolidinediones (TZDs) on contributing to heart failure and cardiac ischemia/reperfusion (IR) injury is controversial. In this study we investigated the effect of select TZDs on myocardial ...
-
(Clinical Infectious Diseases, 2020-03-15)Background. Public health and infection control prevention and surveillance efforts in the United States have primarily focused on methicillin-resistant Staphylococcus aureus (MRSA). We describe the public health importance ...
-
(PLOS Pathogens, 2019-06)Streptococcus gordonii and Streptococcus sanguinis are primary colonizers of the tooth surface. Although generally non-pathogenic in the oral environment, they are a frequent cause of infective endocarditis. Both streptococcal ...