Show simple item record

Immune regulation and evasion of acute respiratory virus infection

dc.creatorRogers, Meredith Claire
dc.description.abstractViral respiratory infections, including infection by human metapneumovirus (HMPV), are associated with T cell impairment, wherein CD8+ T cells exhibit diminished production of cytokines and cytotoxic molecules. In this thesis I show that CD4+ regulatory T cells (Tregs) contribute to decreased CD8+ T cell function and impair clearance of HMPV. Additionally, I demonstrate a temporal role of Tregs in respiratory virus infection, where Tregs are essential during immune priming to promote cell migration and to control the balance of type 1 and type 2 immunity. In this work, I also explored the role of the inhibitory ligand PD-L1 in T cell impairment. PD-L1 is the primary ligand that for the inhibitory receptor PD-1, and antibody blockade of PD-L1 restored CD8+ T cell function in T cell impairment. I found that paradoxically, however, mice genetically deficient in PD-L1 have even further reduced T cell function and antiviral immunity during respiratory virus infection. Finally, I investigated the host species permissiveness of HMPV and found that this is limited by the virus’ capacity to antagonize the interferon signaling pathway of primates and mice.
dc.subjectregulatory t cell
dc.subjectinhibitory receptor
dc.subjectrespiratory virus
dc.titleImmune regulation and evasion of acute respiratory virus infection
dc.contributor.committeeMemberAmbra Pozzi
dc.contributor.committeeMemberTerence Dermody
dc.contributor.committeeMemberDaniel Moore
dc.contributor.committeeMemberJohn V. Williams
dc.type.materialtext and Immunology University
dc.contributor.committeeChairR. Stokes Peebles

Files in this item


This item appears in the following Collection(s)

Show simple item record