• About
    • Login
    View Item 
    •   Institutional Repository Home
    • Electronic Theses and Dissertations
    • Electronic Theses and Dissertations
    • View Item
    •   Institutional Repository Home
    • Electronic Theses and Dissertations
    • Electronic Theses and Dissertations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of Institutional RepositoryCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    The Role of Activin Receptor-like Kinases and Nuclear Factor κB in Type III Transforming Growth Factor β Receptor Signaling

    Robinson, Jamille Yvette
    : https://etd.library.vanderbilt.edu/etd-11262012-232542
    http://hdl.handle.net/1803/14814
    : 2012-12-07

    Abstract

    Congenital heart disease (CHD) is the most common type of birth defect affecting eight out of every 1,000 newborns, causing more deaths in the first year of life than any other birth defect. A significant fraction of CHD is associated with abnormal valve structure and function. A detailed understanding of the early signaling events that regulate and guide cardiac valve formation is required to identify new therapeutic targets. Here, I focus on the role of Type III Transforming Growth Factor β Receptor (TGFβR3) in Endocardial epithelial to mesenchymal transformation (EMT), a critical step in valvular development. Using an in vitro assay of endocardial EMT I used small molecule inhibitors to establish that ALK2 and ALK3 are both required for endocardial EMT. Specifically, I demonstrated that ALK2 and ALK3 are downstream of TGFβR3. Finally, I used small molecule inhibitors of the NF-κB pathway to implicate this signaling system in endocardial EMT. These studies identify and clarify the role of specific pathways endocardial EMT which furthers our understanding of TGFβR3 signaling and early valve formation.
    Show full item record

    Files in this item

    Icon
    Name:
    JRobinson.pdf
    Size:
    1.528Mb
    Format:
    PDF
    View/Open

    This item appears in the following collection(s):

    • Electronic Theses and Dissertations

    Connect with Vanderbilt Libraries

    Your Vanderbilt

    • Alumni
    • Current Students
    • Faculty & Staff
    • International Students
    • Media
    • Parents & Family
    • Prospective Students
    • Researchers
    • Sports Fans
    • Visitors & Neighbors

    Support the Jean and Alexander Heard Libraries

    Support the Library...Give Now

    Gifts to the Libraries support the learning and research needs of the entire Vanderbilt community. Learn more about giving to the Libraries.

    Become a Friend of the Libraries

    Quick Links

    • Hours
    • About
    • Employment
    • Staff Directory
    • Accessibility Services
    • Contact
    • Vanderbilt Home
    • Privacy Policy