dc.creator | Krakowiak, Michelle Stokes | |
dc.date.accessioned | 2020-08-23T15:41:52Z | |
dc.date.available | 2014-10-31 | |
dc.date.issued | 2012-10-31 | |
dc.identifier.uri | https://etd.library.vanderbilt.edu/etd-10302012-135509 | |
dc.identifier.uri | http://hdl.handle.net/1803/14396 | |
dc.description.abstract | This project was conducted to further elucidate the role of matrix metalloproteinase 7 (MMP7) in the pathogenesis of the carcinogenic bacteria Helicobacter pylori. Specifically, in this thesis I discuss the role of MMP7 in H. pylori-induced inflammation and injury. Briefly, we performed histological and molecular biological analysis of stomach tissue from wild-type and MMP7-/- mice that had been challenged with H. pylori. We also performed molecular biological analyses of macrophages extracted from the stomachs or derived from bone marrow of wild-type and MMP7-/- mice. We found that loss of MMP7 results in increased production of inflammatory cytokines, and that MMP-/- macrophages display enhanced M1 macrophage phenotypes. In this research we discovered an explanation for the increased inflammation and injury seen in MMP7-/- mice and thus, a potential role for MMP7 in protecting wild-type animals from H. pylori- induced inflammation. | |
dc.format.mimetype | application/pdf | |
dc.subject | macrophage polarization | |
dc.subject | Models of H. pylori infection | |
dc.subject | bone-marrow derived macrophages | |
dc.title | Matrix Metalloproteinase 7 Supresses M1 Macrophage Polarization to Protect Against Helicobacter pylori-induced Gastric Inflammation | |
dc.type | thesis | |
dc.type.material | text | |
thesis.degree.name | MS | |
thesis.degree.level | thesis | |
thesis.degree.discipline | Cancer Biology | |
thesis.degree.grantor | Vanderbilt University | |
local.embargo.terms | 2014-10-31 | |
local.embargo.lift | 2014-10-31 | |
dc.contributor.committeeChair | Richard Peek | |