dc.creator | Daniels, Richard Nathan | |
dc.date.accessioned | 2020-08-22T21:08:02Z | |
dc.date.available | 2010-09-28 | |
dc.date.issued | 2010-09-28 | |
dc.identifier.uri | https://etd.library.vanderbilt.edu/etd-09272010-171411 | |
dc.identifier.uri | http://hdl.handle.net/1803/14242 | |
dc.description.abstract | This dissertation describes advances in total synthesis, synthetic methodology, and chemical biology. The total synthesis and stereochemical revision of Ciliatamides A-C will be discussed in detail. Also, the total synthesis of 8-epi-Lucentamycin A will be described. Lastly discussed is the development of microwave methodology to improve the synthesis of pyrazolo[1,5-a]pyrimidines. This new methodology was used to rapidly optimize a lead pyrazolo[1,5-a]pyrimidine screening hit into a highly selective and potent bone morphogenetic protein (BMP) inhibitor as well as selective KDR inhibitors using zebrafish as an in vivo screening tool. | |
dc.format.mimetype | application/pdf | |
dc.subject | Bone Morphogenetic Protein | |
dc.subject | Total Synthesis | |
dc.subject | Microwave Methodolgy | |
dc.subject | Medicinal Chemistry | |
dc.title | Total Synthesis and Stereochemical Revision of Ciliatamides A-C, Total Synthesis of 8-epi-Lucentamycin A, and Development of Microwave Methodology to Facilitate the Synthesis of BMP Inhibitors | |
dc.type | dissertation | |
dc.contributor.committeeMember | Brian O. Bachmann | |
dc.contributor.committeeMember | Charles C. Hong | |
dc.contributor.committeeMember | Gary A. Sulikowski | |
dc.type.material | text | |
thesis.degree.name | PHD | |
thesis.degree.level | dissertation | |
thesis.degree.discipline | Chemistry | |
thesis.degree.grantor | Vanderbilt University | |
local.embargo.terms | 2010-09-28 | |
local.embargo.lift | 2010-09-28 | |
dc.contributor.committeeChair | Craig W. Lindsley | |