dc.creator | Thiel, Kristina Wyatt | |
dc.date.accessioned | 2020-08-22T20:44:17Z | |
dc.date.available | 2008-10-03 | |
dc.date.issued | 2007-10-03 | |
dc.identifier.uri | https://etd.library.vanderbilt.edu/etd-08072007-192935 | |
dc.identifier.uri | http://hdl.handle.net/1803/13845 | |
dc.description.abstract | The ErbB family of receptor tyrosine kinases regulates cell growth, differentiation, and tumorigenesis. This dissertation contains two independent studies of ErbB-1 and ErbB-4. In one study, the intracellular juxtamembrane region of ErbB-1 was investigated for its role in kinase activation. By creating deletions and mutations in the juxtamembrane region of ErbB-1, the data defined an essential requirement for the juxtamembrane region in the allosteric mechanism of tyrosine kinase activation. The second study focused on proteolytic processing of ErbB-4. Activation of ErbB-4 results in ectodomain and transmembrane domain cleavage events, but the parameters that must be fulfilled to initiate ectodomain proteolysis remain poorly defined. The localization of ErbB-4 and its sheddase to membrane microdomains was evaluated as a regulatory step in sequential proteolytic processing. | |
dc.format.mimetype | application/pdf | |
dc.subject | ErbB-1 | |
dc.subject | epidermal growth factor receptor | |
dc.subject | receptor tyrosine kinase | |
dc.subject | lipid rafts | |
dc.subject | detergent-insoluble fraction | |
dc.subject | ErbB-4 | |
dc.subject | tumor necrosis factor-alpha converting enzyme | |
dc.subject | Enzyme activation | |
dc.subject | Protein-tyrosine kinase -- Receptors | |
dc.title | Analysis of ErbB Receptors: Regulation of ErbB-1 Kinase Activation and Localization of ErbB-4 to Membrane Microdomains | |
dc.type | dissertation | |
dc.contributor.committeeMember | Bruce Carter | |
dc.contributor.committeeMember | Robert Coffey | |
dc.contributor.committeeMember | Anne Kenworthy | |
dc.contributor.committeeMember | Charles Sanders | |
dc.type.material | text | |
thesis.degree.name | PHD | |
thesis.degree.level | dissertation | |
thesis.degree.discipline | Biochemistry | |
thesis.degree.grantor | Vanderbilt University | |
local.embargo.terms | 2008-10-03 | |
local.embargo.lift | 2008-10-03 | |
dc.contributor.committeeChair | Graham Carpenter | |