dc.creator | Hayes, John Philip | |
dc.date.accessioned | 2020-08-22T17:42:46Z | |
dc.date.available | 2018-07-28 | |
dc.date.issued | 2016-07-27 | |
dc.identifier.uri | https://etd.library.vanderbilt.edu/etd-07202016-172138 | |
dc.identifier.uri | http://hdl.handle.net/1803/13343 | |
dc.description.abstract | Human milk oligosaccharides (HMOs) are a diverse class of carbohydrates that are unique to human milk. These oligosaccharides have been demonstrated to influence infant health through several mechanisms including helping to establish a healthy gut microbiome and deterring pathogenic infection. To understand the manner through which HMOs impart these benefits, it is important to conduct studies using single-entity compounds. The difficulty in isolating pure oligosaccharides from breastmilk has created a demand to access these carbohydrates synthetically.
This work aimed to synthesize the human milk tetrasaccharide lacto-N-neotetraose. In the synthesis, an orthogonal protecting group strategy was employed to facilitate access to human milk pentasaccharides. | |
dc.format.mimetype | application/pdf | |
dc.subject | human milk oligosaccharide | |
dc.subject | HMO | |
dc.subject | carbohydrate synthesis | |
dc.subject | carbohydrates | |
dc.subject | lacto-n-neotetraose | |
dc.subject | LNnT | |
dc.subject | human milk tetrasaccharide | |
dc.subject | orthogonal protecting groups | |
dc.title | Studies Toward the Chemical Synthesis of Lacto-N-neotetraose | |
dc.type | thesis | |
dc.contributor.committeeMember | Gary Sulikowski | |
dc.type.material | text | |
thesis.degree.name | MS | |
thesis.degree.level | thesis | |
thesis.degree.discipline | Chemistry | |
thesis.degree.grantor | Vanderbilt University | |
local.embargo.terms | 2018-07-28 | |
local.embargo.lift | 2018-07-28 | |
dc.contributor.committeeChair | Steven Townsend | |