• About
    • Login
    View Item 
    •   Institutional Repository Home
    • Electronic Theses and Dissertations
    • Electronic Theses and Dissertations
    • View Item
    •   Institutional Repository Home
    • Electronic Theses and Dissertations
    • Electronic Theses and Dissertations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of Institutional RepositoryCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Characterization of the Function and Localization of the Alpha2A-Adrenergic Receptor in the Bed Nucleus of the Stria Terminalis

    Shields, Angela Delight
    : https://etd.library.vanderbilt.edu/etd-06122009-161841
    http://hdl.handle.net/1803/12534
    : 2009-06-15

    Abstract

    The bed nucleus of the stria terminalis (BNST) is a region of the brain critical in mediating behavioral and physiological responses to stress and anxiety. Stress is a major cause of relapse for drug addicts attempting to abstain from drugs of abuse. The BNST receives a dense projection of the stress hormone norepinephrine (NE) from the nucleus tractus solitarus, and this projection is critical in stress-induced relapse to drug-seeking in rodent models. NE acts via adrenergic receptors (AR), including the alpha2A-AR subtype of the alpha2-ARs. This thesis describes work utilizing electrophysiology and immunohistochemistry approaches to characterize the function and localization of the alpha2A-AR in the dorsal BNST. We provide evidence supporting a heterosynaptic localization of the alpha2A-AR on presynaptic glutamate terminals where it functions to regulate glutamate release. We also demonstrate that activation of alpha2-ARs modulates GABAergic transmission in the dorsal BNST.
    Show full item record

    Files in this item

    Icon
    Name:
    ShieldsADTHESIS.pdf
    Size:
    4.794Mb
    Format:
    PDF
    View/Open

    This item appears in the following collection(s):

    • Electronic Theses and Dissertations

    Connect with Vanderbilt Libraries

    Your Vanderbilt

    • Alumni
    • Current Students
    • Faculty & Staff
    • International Students
    • Media
    • Parents & Family
    • Prospective Students
    • Researchers
    • Sports Fans
    • Visitors & Neighbors

    Support the Jean and Alexander Heard Libraries

    Support the Library...Give Now

    Gifts to the Libraries support the learning and research needs of the entire Vanderbilt community. Learn more about giving to the Libraries.

    Become a Friend of the Libraries

    Quick Links

    • Hours
    • About
    • Employment
    • Staff Directory
    • Accessibility Services
    • Contact
    • Vanderbilt Home
    • Privacy Policy