dc.creator | Fleming, Jonathan Tyler | |
dc.date.accessioned | 2020-08-22T00:34:54Z | |
dc.date.available | 2016-04-30 | |
dc.date.issued | 2014-04-30 | |
dc.identifier.uri | https://etd.library.vanderbilt.edu/etd-04162014-131844 | |
dc.identifier.uri | http://hdl.handle.net/1803/12175 | |
dc.description.abstract | Sonic hedgehog (Shh) signaling regulates critical processes during embryonic development and
in homeostasis of adult tissues. Deregulated pathway activity is a major factor underlying the
etiology of numerous developmental disorders and cancers. In this dissertation, I investigated
early neonatal cerebellar development, where I identified that the Purkinje neuron utilizes bidirectional
distribution of Shh to centrally regulate neurogenesis, and to expand a previously
unappreciated stem cell – progenitor cell lineage in the white matter niche. Additionally, I
established a novel mouse model for a soft tissue sarcoma, Ewing’s sarcoma. These findings
provide new understanding of how the Purkinje neuron oversees cerebellar development, as well
as key insight into the molecular underpinnings of a Shh-driven sarcoma variant. | |
dc.format.mimetype | application/pdf | |
dc.subject | Sonic hedgehog cerebellum sarcoma | |
dc.title | The sonic hedgehog pathway mediates central regulation of cerebellar development and sarcoma phenotypic outcome | |
dc.type | dissertation | |
dc.contributor.committeeMember | Andrea Page-McCaw | |
dc.contributor.committeeMember | David Miller, PhD | |
dc.contributor.committeeMember | Anna Means, PhD | |
dc.type.material | text | |
thesis.degree.name | PHD | |
thesis.degree.level | dissertation | |
thesis.degree.discipline | Cell and Developmental Biology | |
thesis.degree.grantor | Vanderbilt University | |
local.embargo.terms | 2016-04-30 | |
local.embargo.lift | 2016-04-30 | |
dc.contributor.committeeChair | James R Goldenring, MD. PhD | |