dc.creator | Lee, Sora | |
dc.date.accessioned | 2020-08-22T00:29:48Z | |
dc.date.available | 2014-04-18 | |
dc.date.issued | 2013-04-18 | |
dc.identifier.uri | https://etd.library.vanderbilt.edu/etd-04092013-122252 | |
dc.identifier.uri | http://hdl.handle.net/1803/12085 | |
dc.description.abstract | Neuroblastomas express increased levels of gastrin-releasing peptide receptor (GRPR). However, the exact molecular mechanisms involved in GRPR-mediated cell signaling in neuroblastoma growth and metastasis are unknown. In this dissertation, I demonstrate that focal adhesion kinase (FAK), as a critical downstream target of GRPR, is an important regulator of neuroblastoma growth and metastasis. I modulated the expression of GRPR and FAK in cells and tested their functional role in tumor progression in vitro and in vivo. Additionally, I investigated the role of Integrins in regulation of FAK activation and cell migration in GRPR overexpressing neuroblastoma cells. Moreover, I evaluated the effect of a FAK inhibitor in vivo, which suppressed GRP-induced neuroblastoma growth and metastasis. Our results indicate that FAK is a critical downstream regulator of GRPR, which mediates tumorigenesis and metastasis in neuroblastoma. | |
dc.format.mimetype | application/pdf | |
dc.subject | GRPR | |
dc.subject | Neuroblastoma | |
dc.subject | FAK | |
dc.subject | Integrin | |
dc.subject | Metastasis | |
dc.subject | Cancer | |
dc.title | Focal Adhesion Kinase Mediates Gastrin-Releasing Peptide Receptor-Induced Neuroblastoma Progression | |
dc.type | dissertation | |
dc.contributor.committeeMember | Dr. Dai H. Chung | |
dc.contributor.committeeMember | Dr. Jason Jessen | |
dc.contributor.committeeMember | Dr. Ambra Pozzi | |
dc.type.material | text | |
thesis.degree.name | PHD | |
thesis.degree.level | dissertation | |
thesis.degree.discipline | Cancer Biology | |
thesis.degree.grantor | Vanderbilt University | |
local.embargo.terms | 2014-04-18 | |
local.embargo.lift | 2014-04-18 | |
dc.contributor.committeeChair | Dr. Roy Zent | |