dc.creator | Tang, Dewei | |
dc.date.accessioned | 2020-08-21T21:34:12Z | |
dc.date.available | 2015-04-15 | |
dc.date.issued | 2013-04-15 | |
dc.identifier.uri | https://etd.library.vanderbilt.edu/etd-03252013-153516 | |
dc.identifier.uri | http://hdl.handle.net/1803/11305 | |
dc.description.abstract | This project is focused on PET probe development for cancer imaging by targeting a potential cancer biomarker- Translocator Protein (TSPO). In this project, I evaluated 18F-DPA-714, a pyrazolopyrimindine probe, as a TSPO PET probe for C6 glioma preclinical imaging. With in vivo PET imaging study, I evaluated 18F-DPA-714 as a promising tracer in detecting C6 glioma in rats. With following optimization of this probe, I discovered 18F-VUIIS1008, a TSPO PET probe featuring a 36-fold higher binding affinity compared to 18F-DPA-714. Further preclinical PET imaging with 18F-VUIIS1008 demonstrated a partial reversible binding profile to tumor instead of the healthy brain. Meanwhile, I also found that 18F-VUIIS1008 demonstrated a higher in vivo stability and lower brain uptake compared to 18F-DPA-714. According to these result, we envision this 18F-VUIIS1008 holds a great potential to serve as a PET probe for the human glioma imaging. | |
dc.format.mimetype | application/pdf | |
dc.subject | TSPO | |
dc.subject | Cancer Imaging | |
dc.subject | Pyrazolopyrimidines | |
dc.subject | Positron Emission Tomography | |
dc.subject | DPA-714 | |
dc.subject | Glioma | |
dc.title | Synthesis and evaluation of pyrazolopyrimidinyl-based TSPO ligands for cancer imaging | |
dc.type | dissertation | |
dc.contributor.committeeMember | John C. Gore | |
dc.contributor.committeeMember | Robert J. Coffey | |
dc.contributor.committeeMember | Thomas E. Yankeelov | |
dc.contributor.committeeMember | Brian O. Bachmann | |
dc.type.material | text | |
thesis.degree.name | PHD | |
thesis.degree.level | dissertation | |
thesis.degree.discipline | Chemical and Physical Biology | |
thesis.degree.grantor | Vanderbilt University | |
local.embargo.terms | 2015-04-15 | |
local.embargo.lift | 2015-04-15 | |
dc.contributor.committeeChair | H.Charles Manning | |