dc.creator | Manhard, Mary Katherine | |
dc.date.accessioned | 2020-08-21T21:33:54Z | |
dc.date.available | 2014-04-15 | |
dc.date.issued | 2013-04-15 | |
dc.identifier.uri | https://etd.library.vanderbilt.edu/etd-03252013-092750 | |
dc.identifier.uri | http://hdl.handle.net/1803/11298 | |
dc.description.abstract | Clinically compatible ultra-short echo time (UTE) imaging sequences for quantitative T2-based bound and pore water imaging in bone were implemented and validated on a 3T human scanner and a 4.7T small bore system. Pore water images were generated by selectively saturating bound water signals with a T2-selective double adiabatic inversion pulse. Bound water images were generated by nulling the pore water signals with a T2-selective adiabatic inversion recovery preparation. In both cases, the magnetization preparation was integrated into a 3D UTE acquisition, with 16 radial spokes acquired per preparation. Images were acquired from human cadaveric femoral mid-shafts, from which isolated bone samples were subsequently extracted for non-imaging analysis using T2 spectroscopic measurements. The results showed a strong correlation between imaging-derived concentrations of bound and pore water and those determined from the isolated bone samples. | |
dc.format.mimetype | application/pdf | |
dc.subject | 3T and 4.7T | |
dc.subject | ultra-short MRI | |
dc.subject | cortical bone | |
dc.subject | adiabatic inversion | |
dc.title | Validation of Quantitative Bound and Pore Water Imaging in Cortical Bone | |
dc.type | thesis | |
dc.contributor.committeeMember | Adam Anderson | |
dc.type.material | text | |
thesis.degree.name | MS | |
thesis.degree.level | thesis | |
thesis.degree.discipline | Biomedical Engineering | |
thesis.degree.grantor | Vanderbilt University | |
local.embargo.terms | 2014-04-15 | |
local.embargo.lift | 2014-04-15 | |
dc.contributor.committeeChair | Mark D. Does | |