TIP-1, a new biomarker for radiotherapy, regulates migration and invasion of human gliomas through Rho GTPases

Abstract

Cancer targeted imaging plays an important role in cancer diagnosis. It allows us to rapidly evaluate tumor responses to certain treatments. Peptide-based imaging probes have been widely used in cancer targeted imaging. With the development of phage display technology, a great number of peptides have been identified specifically targeting to tumor cells in vitro and in vivo. However, due to peptides small size and relatively low binding affinity, it is difficult to identify the target of peptides. This thesis research is focusing on: i). identifying the target of specific peptide – HVGGSSV, which bind to radiation responsive tumors, by utilizing several affinity purification techniques especially the phage display screening; and validating the target as a marker for evaluation of radiation treatment; ii). exploring the biological functions of the targeting protein.