• About
    • Login
    View Item 
    •   Institutional Repository Home
    • Electronic Theses and Dissertations
    • Electronic Theses and Dissertations
    • View Item
    •   Institutional Repository Home
    • Electronic Theses and Dissertations
    • Electronic Theses and Dissertations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of Institutional RepositoryCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsDepartmentThis CollectionBy Issue DateAuthorsTitlesSubjectsDepartment

    My Account

    LoginRegister

    Development of polyurethane scaffolds with controlled mechanical strength and inner structure as potential cell/drug delivery system for tissue regeneration

    Guo, Ruijing
    : https://etd.library.vanderbilt.edu/etd-03232015-111437
    http://hdl.handle.net/1803/11134
    : 2015-04-08

    Abstract

    For the application of cell therapy in tissue repair, there is a compelling need for the development of suitable cell carriers, which will function as synthetic analogs of the extracelluar matrix (ECM) that provide a substrate for transplanted cell adhesion, control the localization of the cells in vivo, and serve as a template for the formation of new tissue masses from the combination of transplanted cells and interfacing host cells. Polyurethane can be served as a polymer carrier with adjustable characteristics for multi-purpose usage in cell delivery system. In the meanwhile, the influence of physical properties of polyurethane scaffolds on cell growth and engraftment in the wounded sites is also necessary to be clarified by understanding the molecular mechanism between cell-biomaterial interactions and thus the wound healing process will be able to be optimally controlled by modifying the applied polyurethane properties. The goal of this dissertation was to develop a cell carrier system with tunable physical properties for mesenchymal stem cell delivery to restore tissue function by supplying the multiple factors required for healing from the regenerative stem cells. Two-component polyurethanes were used as the carrier of cell delivery system as well as to help peripheral tissue infiltrate into the defect sites. The mechanical properties of polyurethane are modified by changing the structures of hard and soft segments, which is easily achieved by controlling the chain length of polyol and isocyanate in the reaction, while the structure of the 3D scaffolds were precisely controlled by a new templated-Fused Deposition Modeling (t-FDM) process with the computer aided 3D-printing technique. Cellular response and molecular mechanism were studies in vitro and in vivo. Therefore, a potentially translational cell delivery system with control over cell fate was developed and characterized in the presented dissertation.
    Show full item record

    Files in this item

    Icon
    Name:
    GUO.pdf
    Size:
    2.619Mb
    Format:
    PDF
    View/Open

    This item appears in the following collection(s):

    • Electronic Theses and Dissertations

    Connect with Vanderbilt Libraries

    Your Vanderbilt

    • Alumni
    • Current Students
    • Faculty & Staff
    • International Students
    • Media
    • Parents & Family
    • Prospective Students
    • Researchers
    • Sports Fans
    • Visitors & Neighbors

    Support the Jean and Alexander Heard Libraries

    Support the Library...Give Now

    Gifts to the Libraries support the learning and research needs of the entire Vanderbilt community. Learn more about giving to the Libraries.

    Become a Friend of the Libraries

    Quick Links

    • Hours
    • About
    • Employment
    • Staff Directory
    • Accessibility Services
    • Contact
    • Vanderbilt Home
    • Privacy Policy