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A Comprehensive Framework for Image Guided Breast Surgery

dc.creatorConley, Rebekah Helene
dc.description.abstractUnfortunately, the current re-excision rates for breast conserving surgeries due to positive margins average 20-40%. The high re-excision rates arise from difficulty in localizing tumor boundaries intraoperatively and lack of real time information on the presence of residual disease. The work presented here introduces the use of supine magnetic resonance (MR) images, digitization technology, and biomechanical models to investigate the capability of using an image guidance system to localize tumors intraoperatively. Two studies are presented in which preoperative supine MR images were registered to a mock intraoperative setup. In the mock intraoperative setup, a laser range scanner was used to digitize the breast surface and tracked ultrasound was used to digitize the chest wall and tumor. In the first study, a rigid registration was performed and validated using subsurface error metrics between the registered preoperative tumor and the intraoperative tumor as identified by tracked ultrasound. In the second study, a novel nonrigid correction technique was employed to correct for deformations occurring between the preoperative and intraoperative states. Tumor localizations by tracked ultrasound were again used to evaluate the fidelity of aligning preoperative MR tumor contours to physical patient space. Using our prototype image guided surgery platform, we were able to align intraoperative data with preoperative patient specific models with clinically relevant accuracy.
dc.subjectnonrigid registration
dc.subjecttracked ultrasound
dc.subjectbiomechanical models
dc.subjectimage guided surgery
dc.subjectbreast conservation therapy
dc.titleA Comprehensive Framework for Image Guided Breast Surgery
dc.contributor.committeeMemberRobert L. Galloway
dc.type.materialtext Engineering University
dc.contributor.committeeChairMichael I. Miga

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