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Modulation of Beta-Cell Intrinsic and Extrinsic Characteristics by CTGF to Promote Beta-Cell Mass Regeneration.

dc.creatorRiley, Kimberly Ann Gooding
dc.date.accessioned2020-08-21T21:07:34Z
dc.date.available2016-03-25
dc.date.issued2015-03-25
dc.identifier.urihttps://etd.library.vanderbilt.edu/etd-03102015-132801
dc.identifier.urihttp://hdl.handle.net/1803/10722
dc.description.abstractAs diabetes continues to affect millions of people within the United States, identification of novel factors that may enhance beta-cell proliferation and mass regeneration in vivo is critical. Our lab previously demonstrated the requirement of the secreted protein CTGF in endocrine development, specifically beta-cell differentiation and proliferation. However, over-expression of CTGF in normal adult beta-cells does not elicit beta-cell proliferation. Yet, CTGF is re-expressed in adult beta-cells during periods of beta-cell mass expansion, such as pregnancy and high fat diet feeding. Overall, this suggests that CTGF is critical during periods of increased beta-cell demand and beta-cell mass expansion, potentially including beta-cell regeneration. Through genetic mouse models we determined that CTGF over-expression promotes beta-cell regeneration via modulation of beta-cell maturity and proliferation characteristics. This is in addition to CTGF-mediated involvement of the immune system to promote beta-cell regeneration.
dc.format.mimetypeapplication/pdf
dc.subjectdiabetes
dc.subjectregeneration
dc.subjectbeta-cell
dc.subjectCTGF
dc.subjectpancreas
dc.subjectproliferation
dc.titleModulation of Beta-Cell Intrinsic and Extrinsic Characteristics by CTGF to Promote Beta-Cell Mass Regeneration.
dc.typedissertation
dc.contributor.committeeMemberAndrea Page-McCaw
dc.contributor.committeeMemberAntonis Hatzopoulos
dc.contributor.committeeMemberPampee Young
dc.type.materialtext
thesis.degree.namePHD
thesis.degree.leveldissertation
thesis.degree.disciplineCell and Developmental Biology
thesis.degree.grantorVanderbilt University
local.embargo.terms2016-03-25
local.embargo.lift2016-03-25
dc.contributor.committeeChairGuoqiang Gu


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