dc.creator | Riley, Kimberly Ann Gooding | |
dc.date.accessioned | 2020-08-21T21:07:34Z | |
dc.date.available | 2016-03-25 | |
dc.date.issued | 2015-03-25 | |
dc.identifier.uri | https://etd.library.vanderbilt.edu/etd-03102015-132801 | |
dc.identifier.uri | http://hdl.handle.net/1803/10722 | |
dc.description.abstract | As diabetes continues to affect millions of people within the United States, identification of novel factors that may enhance beta-cell proliferation and mass regeneration in vivo is critical. Our lab previously demonstrated the requirement of the secreted protein CTGF in endocrine development, specifically beta-cell differentiation and proliferation. However, over-expression of CTGF in normal adult beta-cells does not elicit beta-cell proliferation. Yet, CTGF is re-expressed in adult beta-cells during periods of beta-cell mass expansion, such as pregnancy and high fat diet feeding. Overall, this suggests that CTGF is critical during periods of increased beta-cell demand and beta-cell mass expansion, potentially including beta-cell regeneration. Through genetic mouse models we determined that CTGF over-expression promotes beta-cell regeneration via modulation of beta-cell maturity and proliferation characteristics. This is in addition to CTGF-mediated involvement of the immune system to promote beta-cell regeneration. | |
dc.format.mimetype | application/pdf | |
dc.subject | diabetes | |
dc.subject | regeneration | |
dc.subject | beta-cell | |
dc.subject | CTGF | |
dc.subject | pancreas | |
dc.subject | proliferation | |
dc.title | Modulation of Beta-Cell Intrinsic and Extrinsic Characteristics by CTGF to Promote Beta-Cell Mass Regeneration. | |
dc.type | dissertation | |
dc.contributor.committeeMember | Andrea Page-McCaw | |
dc.contributor.committeeMember | Antonis Hatzopoulos | |
dc.contributor.committeeMember | Pampee Young | |
dc.type.material | text | |
thesis.degree.name | PHD | |
thesis.degree.level | dissertation | |
thesis.degree.discipline | Cell and Developmental Biology | |
thesis.degree.grantor | Vanderbilt University | |
local.embargo.terms | 2016-03-25 | |
local.embargo.lift | 2016-03-25 | |
dc.contributor.committeeChair | Guoqiang Gu | |