dc.creator | Ogden, Seth Rayborn | |
dc.date.accessioned | 2020-08-21T21:05:09Z | |
dc.date.available | 2009-03-03 | |
dc.date.issued | 2009-03-03 | |
dc.identifier.uri | https://etd.library.vanderbilt.edu/etd-03032009-131726 | |
dc.identifier.uri | http://hdl.handle.net/1803/10659 | |
dc.description.abstract | Gastric adenocarcinoma is strongly associated with the presence of H. pylori, and both microbial and host factors influence the risk for carcinogenesis. A novel role for H. pylori in the stimulation of the p120ctn/Kaiso signaling axis leading to relief of Kaiso-mediated repression of mmp-7 transcription in vitro was identified. Increased expression of MMP-7 in response to H. pylori infection may alter a number of processes involved in carcinogenesis, including the inflammatory response, proliferation, and apoptosis. Bacterial challenge of mice deficient in MMP-7 resulted in enhanced inflammation and cellular turnover when compared to wild type mice, suggesting that MMP-7 may serve a protective role within H. pylori-infected gastric mucosa. Taken together, these data indicate that H. pylori stimulates increased gene transcription through dysregulation of a number of signaling pathways and that upregulation of these host effectors mediates the development of malignant lesions. | |
dc.format.mimetype | application/pdf | |
dc.subject | p120 | |
dc.subject | p120-catenin | |
dc.subject | matrix metalloproteinase-7 | |
dc.subject | MMP-7 | |
dc.subject | Helicobacter pylori | |
dc.subject | Helicobacter pylori infections -- Pathophysiology | |
dc.subject | Stomach -- Cancer -- Etiology | |
dc.subject | Cell adhesion molecules | |
dc.subject | Metalloproteinases | |
dc.title | Helicobacter pylori-mediated dysregulation of p120-catenin and matrix metalloproteinase-7 | |
dc.type | dissertation | |
dc.contributor.committeeMember | Timothy L. Cover | |
dc.contributor.committeeMember | Albert B. Reynolds | |
dc.contributor.committeeMember | Richard M. Peek, Jr. | |
dc.type.material | text | |
thesis.degree.name | PHD | |
thesis.degree.level | dissertation | |
thesis.degree.discipline | Cancer Biology | |
thesis.degree.grantor | Vanderbilt University | |
local.embargo.terms | 2009-03-03 | |
local.embargo.lift | 2009-03-03 | |
dc.contributor.committeeChair | Barbara Fingleton | |