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New Modes of B lymphocyte Regulation in Autoimmune Disease

dc.creatorWilson, Christopher Scott
dc.description.abstractNew Modes of B lymphocyte Regulation in Autoimmune Disease Christopher Scott Wilson Dissertation under the direction of Professor Daniel J. Moore The deleterious roles that B lymphocytes play in autoimmunity and regulation of immune tolerance are well documented in the literature. B lymphocytes are thought to mediate autoimmunity primarily through presentation of autoantigens to T lymphocytes. Targeting B lymphocytes by depletion clinically in autoimmune disease has been attempted with varying levels of success. The failure of current clinical approaches may be the result of a deficit in our understanding of the role of B lymphocytes in autoimmune disease. B lymphocytes possess multiple functions which, depending on context, may mediate distinct immunologic outcomes. Certain instances have indicated that B lymphocytes can mediate immune regulation. Targeting B lymphocyte function and homeostasis in autoimmune disease revealed novel ways that B lymphocyte regulate organ damage and reverse autoimmune disease. This work highlights new ways to foster B lymphocyte regulation of autoimmune disease.
dc.subjectB cells
dc.subjectType 1 Diabetes
dc.titleNew Modes of B lymphocyte Regulation in Autoimmune Disease
dc.contributor.committeeMemberWilliam E. Russell
dc.contributor.committeeMemberJonathan M. Irish
dc.contributor.committeeMemberMark R. Boothby
dc.contributor.committeeMemberDaniel J. Moore
dc.type.materialtext and Immunology University
dc.contributor.committeeChairJames W. Thomas

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