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The Role of the Prostaglandin E2 EP3 Receptor in Obesity, Insulin Resistance, and Glycemic Control
(2015-12-01)
Mice carrying a targeted disruption of the prostaglandin E2 E-prostanoid receptor 3 (EP3) gene, Ptger3, were fed a high-fat diet (HFD), or a micronutrient matched control diet, to investigate the effects of disrupted ...
“I’m The One That Understands What’s Happening To Me”: Sensemaking Narratives of People with Type I Diabetes
(2017-12-08)
While healthcare research has examined how social and emotional factors complicate treatment of chronic disease, practitioners often have few resources to assess and address the impact of non-biological influences on patient ...
The multifaceted role of eosinophils in adipose tissue: from metabolism to allergy
(2017-12-12)
Obesity has reached epidemic proportions worldwide, with some of the greatest severity in the United States. The most recent data reports ~70% of the American population is overweight (BMI ≥ 25 kg/m2) and ~35% obese (BMI ...
Regulation of insulin resistance by Cyp2c44-derived lipids
(2016-11-22)
Type 2 diabetes affects 10% of the United States population, and patients with diabetes have an increased risk for diseases such as atherosclerosis and hypertension. Since all these diseases are associated with insulin ...
Dopaminergic regulation of insulin secretion from the pancreatic islet
(2012-12-11)
Insulin secretion is the natural response to hyperglycemia, and it is crucial to maintain glucose homeostasis in healthy individuals. Impairment in this regulation eventually results in Type-2 diabetes. From the perspective ...
Transcriptional Profiling of Pancreatic Progenitor Cells
(2011-12-04)
Pluripotent stem cells, because of their ability to differentiate into any cell type, have been widely advocated as a means of producing a nearly unlimited source of new insulin-producing β cells for the treatment of ...
Development of Optical Imaging Methods for Evaluating the Vascular Response to Hind Limb Ischemia
(2015-11-23)
Peripheral arterial disease (PAD) affects millions of individuals and increases the risk of myocardial infarction, stroke, and mortality. Compared to the general population, diabetic patients have a four times greater risk ...
Gene expression and copy number variation in common complex diseases
(2010-12-17)
Common, complex diseases are not caused by a single gene mutation but rather have genetic and environmental components. As a subset, autoimmune diseases also possess robust gene expression signatures that have both genetic ...
Variables that influence transcription factor-mediated acinar to beta cell reprogramming
(2017-02-24)
Reprogramming of pancreatic cells into new beta-like cells is a potential therapy for Type 1 diabetes. Pancreatic acinar cells are an appealing target for cellular reprogramming since they are abundant, derived from a ...
Synaptotagmin IV and Myt factors promote β-cell functional maturation and maintenance
(2017-03-31)
Both type I and type II diabetes are related to β-cell defects in the pancreatic islet of Langerhans. Deriving β-cells from stem cells and other mature cell types provides an important cell source for transplantation-based ...